PCL-ZnO/TiO<sub>2</sub>/HAp Electrospun Composite Fibers with Applications in Tissue Engineering
The main objective of the tissue engineering field is to regenerate the damaged parts of the body by developing biological substitutes that maintain, restore, or improve original tissue function. In this context, by using the electrospinning technique, composite scaffolds based on polycaprolactone (...
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MDPI AG
2019-11-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/11/11/1793 |
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doaj-a98bc463f5de4da89f241714566a65c72020-11-25T02:32:55ZengMDPI AGPolymers2073-43602019-11-011111179310.3390/polym11111793polym11111793PCL-ZnO/TiO<sub>2</sub>/HAp Electrospun Composite Fibers with Applications in Tissue EngineeringSorin-Ion Jinga0Andreea-Ioana Zamfirescu1Georgeta Voicu2Monica Enculescu3Alexandru Evanghelidis4Cristina Busuioc5Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, RO-011061 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, RO-011061 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, RO-011061 Bucharest, RomaniaLaboratory of Multifunctional Materials and Structures, National Institute of Materials Physics, RO-077125 Magurele, RomaniaLaboratory of Multifunctional Materials and Structures, National Institute of Materials Physics, RO-077125 Magurele, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, RO-011061 Bucharest, RomaniaThe main objective of the tissue engineering field is to regenerate the damaged parts of the body by developing biological substitutes that maintain, restore, or improve original tissue function. In this context, by using the electrospinning technique, composite scaffolds based on polycaprolactone (PCL) and inorganic powders were successfully obtained, namely: zinc oxide (ZnO), titanium dioxide (TiO<sub>2</sub>) and hydroxyapatite (HAp). The novelty of this approach consists in the production of fibrous membranes based on a biodegradable polymer and loaded with different types of mineral powders, each of them having a particular function in the resulting composite. Subsequently, the precursor powders and the resulting composite materials were characterized by the structural and morphological point of view in order to determine their applicability in the field of bone regeneration. The biological assays demonstrated that the obtained scaffolds represent support that is accepted by the cell cultures. Through simulated body fluid immersion, the biodegradability of the composites was highlighted, with fiber fragmentation and surface degradation within the testing period.https://www.mdpi.com/2073-4360/11/11/1793fiberscompositesscaffoldselectrospinningtissue engineering |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sorin-Ion Jinga Andreea-Ioana Zamfirescu Georgeta Voicu Monica Enculescu Alexandru Evanghelidis Cristina Busuioc |
| spellingShingle |
Sorin-Ion Jinga Andreea-Ioana Zamfirescu Georgeta Voicu Monica Enculescu Alexandru Evanghelidis Cristina Busuioc PCL-ZnO/TiO<sub>2</sub>/HAp Electrospun Composite Fibers with Applications in Tissue Engineering Polymers fibers composites scaffolds electrospinning tissue engineering |
| author_facet |
Sorin-Ion Jinga Andreea-Ioana Zamfirescu Georgeta Voicu Monica Enculescu Alexandru Evanghelidis Cristina Busuioc |
| author_sort |
Sorin-Ion Jinga |
| title |
PCL-ZnO/TiO<sub>2</sub>/HAp Electrospun Composite Fibers with Applications in Tissue Engineering |
| title_short |
PCL-ZnO/TiO<sub>2</sub>/HAp Electrospun Composite Fibers with Applications in Tissue Engineering |
| title_full |
PCL-ZnO/TiO<sub>2</sub>/HAp Electrospun Composite Fibers with Applications in Tissue Engineering |
| title_fullStr |
PCL-ZnO/TiO<sub>2</sub>/HAp Electrospun Composite Fibers with Applications in Tissue Engineering |
| title_full_unstemmed |
PCL-ZnO/TiO<sub>2</sub>/HAp Electrospun Composite Fibers with Applications in Tissue Engineering |
| title_sort |
pcl-zno/tio<sub>2</sub>/hap electrospun composite fibers with applications in tissue engineering |
| publisher |
MDPI AG |
| series |
Polymers |
| issn |
2073-4360 |
| publishDate |
2019-11-01 |
| description |
The main objective of the tissue engineering field is to regenerate the damaged parts of the body by developing biological substitutes that maintain, restore, or improve original tissue function. In this context, by using the electrospinning technique, composite scaffolds based on polycaprolactone (PCL) and inorganic powders were successfully obtained, namely: zinc oxide (ZnO), titanium dioxide (TiO<sub>2</sub>) and hydroxyapatite (HAp). The novelty of this approach consists in the production of fibrous membranes based on a biodegradable polymer and loaded with different types of mineral powders, each of them having a particular function in the resulting composite. Subsequently, the precursor powders and the resulting composite materials were characterized by the structural and morphological point of view in order to determine their applicability in the field of bone regeneration. The biological assays demonstrated that the obtained scaffolds represent support that is accepted by the cell cultures. Through simulated body fluid immersion, the biodegradability of the composites was highlighted, with fiber fragmentation and surface degradation within the testing period. |
| topic |
fibers composites scaffolds electrospinning tissue engineering |
| url |
https://www.mdpi.com/2073-4360/11/11/1793 |
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AT sorinionjinga pclznotiosub2subhapelectrospuncompositefiberswithapplicationsintissueengineering AT andreeaioanazamfirescu pclznotiosub2subhapelectrospuncompositefiberswithapplicationsintissueengineering AT georgetavoicu pclznotiosub2subhapelectrospuncompositefiberswithapplicationsintissueengineering AT monicaenculescu pclznotiosub2subhapelectrospuncompositefiberswithapplicationsintissueengineering AT alexandruevanghelidis pclznotiosub2subhapelectrospuncompositefiberswithapplicationsintissueengineering AT cristinabusuioc pclznotiosub2subhapelectrospuncompositefiberswithapplicationsintissueengineering |
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