Influence of Serotonin 5-HT<sub>4</sub> Receptors on Responses to Cardiac Stressors in Transgenic Mouse Models

Influence of Serotonin 5-HT<sub>4</sub> Receptors on Responses to Cardiac Stressors in Transgenic Mouse Models

The current study aimed to deepen our knowledge on the role of cardiac 5-HT<sub>4</sub> receptors under pathophysiological conditions. To this end, we used transgenic (TG) mice that overexpressed human 5-HT<sub>4a</sub> receptors solely in cardiac myocytes (5-HT<sub>4&l...

Full description

Bibliographic Details
Main Authors:	Ulrich Gergs, Timo Gerigk, Jonas Wittschier, Constanze T. Schmidbaur, Clara Röttger, Mareen Mahnkopf, Hanna Edler, Hartmut Wache, Joachim Neumann
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Series:	Biomedicines
Subjects:	serotonin LPS hypoxia ischemia PP2A transgenic mice inflammation
Online Access:	https://www.mdpi.com/2227-9059/9/5/569

Similar Items

Initial Characterization of Stressed Transgenic Mice With Cardiomyocyte-Specific Overexpression of Protein Phosphatase 2C
by: Paula Bollmann, et al.
Published: (2021-01-01)

Serotonin Signalling in Flatworms: An Immunocytochemical Localisation of 5-HT<sub>7</sub> Type of Serotonin Receptors in <i>Opisthorchis felineus</i> and <i>Hymenolepis diminuta</i>
by: Natalia Kreshchenko, et al.
Published: (2021-08-01)

Mechanisms of Systolic Cardiac Dysfunction in PP2A, PP5 and PP2AxPP5 Double Transgenic Mice
by: Mara-Francine Dörner, et al.
Published: (2021-08-01)

The serotonin 5-HT3 receptor: a novel neurodevelopmental target
by: Mareen eEngel, et al.
Published: (2013-05-01)

Effect of acupuncture on Lipopolysaccharide-induced anxiety-like behavioral changes: involvement of serotonin system in dorsal Raphe nucleus
by: Tae Young Yang, et al.
Published: (2017-12-01)

Mitochondrial Membranes of Human SH-SY5Y Neuroblastoma Cells Express Serotonin 5-HT<sub>7</sub> Receptor
by: Alessandra Tempio, et al.
Published: (2020-12-01)

Effects of Subchronic Administrations of Vortioxetine, Lurasidone, and Escitalopram on Thalamocortical Glutamatergic Transmission Associated with Serotonin 5-HT7 Receptor
by: Motohiro Okada, et al.
Published: (2021-01-01)

Pre-gestational stress reduces the ratio of 5-HIAA to 5-HT and the expression of 5-HT1A receptor and serotonin transporter in the brain of foetal rat
by: Huang Yuejun, et al.
Published: (2012-02-01)

Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats
by: Chi Yan, et al.
Published: (2012-10-01)

Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats
by: Chi Yan, et al.
Published: (2012-10-01)

Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT<sub>2A </sub>or 5-HT<sub>2C </sub>receptors
by: Seitz Patricia K, et al.
Published: (2012-03-01)

<i>Htr2a</i> gene and 5-HT<sub>2A</sub> receptor expression in the cerebral cortex studied using genetically modified mice
by: Rodrigo Andrade, et al.
Published: (2010-08-01)

Localization of serotonin (5-hydroxytryptamine, 5-HT) with partial purification and characterization of a serotonin binding protein in the intestinal tissue of the nematode Ascaris suum
by: Martin, Rex E. (Rex Edward)
Published: (1989)

Azologization of serotonin 5-HT3 receptor antagonists
by: Karin Rustler, et al.
Published: (2019-03-01)

Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome
by: Bianca eDe Filippis, et al.
Published: (2015-04-01)

Serotonin Syndrome
by: Harold Muñoz Cortés, et al.
Published: (2004-08-01)

Role of peripheral 5-HT1D, 5-HT3 and 5-HT7 receptors in the mechanical allodynia induced by serotonin in mice
by: Elias B. Nascimento, Jr., et al.
Published: (2021-03-01)

Sex Differences in Serotonin (5-HT) Activity During Safety Learning
by: Fernando, Kayla Dana
Published: (2018)

Serotonin hypothesis and pulmonary artery hypertension
by: Monika Kloza, et al.
Published: (2014-06-01)

Transcriptional Regulation of FEV, a Human Serotonin Neuron Developmental Control Gene
by: Krueger, Katherine C.
Published: (2009)

Serotonin syndrome triggered by postoperative administration of serotonin noradrenaline reuptake inhibitor (SNRI)
by: Junko Takata, et al.
Published: (2019-08-01)

Contribution of Corticotropin-Releasing Factor Receptor 1 (CRF1) to Serotonin Receptor 5-HT<sub>2C</sub>R Function in Amygdala Neurons in a Neuropathic Pain Model
by: Guangchen Ji, et al.
Published: (2019-09-01)

Electrochemical Sensing of Serotonin by a Modified MnO<sub>2</sub>-Graphene Electrode
by: Lavanya Nehru, et al.
Published: (2020-04-01)

Beneficial effects of trimetazidine on expression of serotonin and serotonin transporter in rats with myocardial infarction and depression
by: Liu MY, et al.
Published: (2018-03-01)

SB 206553, a putative 5-HT<sub>2C</sub> inverse agonist, attenuates methamphetamine-seeking in rats
by: Graves Steven M, et al.
Published: (2012-06-01)

Responses of Plasma Catecholamine, Serotonin, and the Platelet Serotonin Transporter to Cigarette Smoking
by: Curtis Lee Lowery, et al.
Published: (2019-03-01)

Effect of the 5-HT<sub>2C</sub> Receptor Agonist WAY-163909 on Serotonin and Dopamine Metabolism across the Rat Brain: A Quantitative and Qualitative Neurochemical Study
by: Sara Whitestone, et al.
Published: (2019-06-01)

Serotonin binding in vitro by releasable proteins from human blood platelets
by: Heemstra, Valerie Lawrence
Published: (1984)

Polymorphism of the 5-HT<sub>2A</sub> receptor gene: Association with stress-related indices in healthy middle-aged adults
by: Alexandra J Fiocco, et al.
Published: (2007-11-01)

Central Serotonin-2A (5-HT2A) Receptor Dysfunction in Depression and Epilepsy: The Missing Link?
by: Bruno Pierre Guiard, et al.
Published: (2015-03-01)

Lurasidone Sub-Chronically Activates Serotonergic Transmission via Desensitization of 5-HT1A and 5-HT7 Receptors in Dorsal Raphe Nucleus
by: Motohiro Okada, et al.
Published: (2019-10-01)

Die funktionelle Bedeutung der Heteromerisierung von Serotonin-1A und Serotonin-7 Rezeptoren
by: Fröhlich, Matthias
Published: (2011)

Overexpression of Pear (<i>Pyrus pyrifolia</i>) <i>CAD2</i> in Tomato Affects Lignin Content
by: Mingtong Li, et al.
Published: (2019-07-01)

Biased Ligands Differentially Shape the Conformation of the Extracellular Loop Region in 5-HT<sub>2B</sub> Receptors
by: Katrin Denzinger, et al.
Published: (2020-12-01)

Modeling the Binding of Inhibitors/Drugs to the Human Serotonin Transporter
by: Immadisetty, Kalyan
Published: (2015)

The PP1 gamma isoforms restore spermatogenesis but not fertility in PP1 gamma null mice
by: Soler, David C.
Published: (2009)

Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis
by: Naozumi eAraragi, et al.
Published: (2013-08-01)

Genetic Background Underlying 5-HT<sub>1A</sub> Receptor Functioning Affects the Response to Fluoxetine
by: Elena M. Kondaurova, et al.
Published: (2020-11-01)

Deciphering serotonin's role in neurodevelopment
Published: (2014)

THE DEVELOPMENT OF INDOLEAMINE DERIVATIVES SELECTIVE FOR SUBTYPES OF SEROTONIN RECEPTORS (TRYPTAMINE, BASILAR ARTERY, ANTAGONIST, ERGOLINE, SYNTHESIS).
by: TAYLOR, ETHAN WILL.
Published: (1985)

Cannot write session to /tmp/vufind_sessions/sess_0j7naptg28rrmbfke8j4ngp1j1