More Favorable Palmitic Acid Over Palmitoleic Acid Modification of Wnt3 Ensures Its Localization and Activity in Plasma Membrane Domains

More Favorable Palmitic Acid Over Palmitoleic Acid Modification of Wnt3 Ensures Its Localization and Activity in Plasma Membrane Domains

While the lateral organization of plasma membrane components has been shown to control binding of Wnt ligands to their receptors preferentially in the ordered membrane domains, the role of posttranslational lipid modification of Wnt on this selective binding is unknown. Here, we identify that the ca...

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Bibliographic Details
Main Authors: Yagmur Azbazdar, Ozgun Ozalp, Erdinc Sezgin, Sapthaswaran Veerapathiran, Anna L. Duncan, Mark S. P. Sansom, Christian Eggeling, Thorsten Wohland, Ezgi Karaca, Gunes Ozhan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ordered plasma membrane domain
lipid raft
Wnt/β-catenin pathway
structural modeling
acylation
palmitoylation
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00281/full

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https://www.frontiersin.org/article/10.3389/fcell.2019.00281/full

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