USP22 Protects Against Myocardial Ischemia–Reperfusion Injury via the SIRT1-p53/SLC7A11–Dependent Inhibition of Ferroptosis–Induced Cardiomyocyte Death

USP22 Protects Against Myocardial Ischemia–Reperfusion Injury via the SIRT1-p53/SLC7A11–Dependent Inhibition of Ferroptosis–Induced Cardiomyocyte Death

Myocardial ischemia–reperfusion (MI/R) injury is characterized by iron deposition and reactive oxygen species production, which can induce ferroptosis. Ferroptosis has also been proposed to promote cardiomyocyte death. The current study sought to define the mechanism governing cardiomyocyte death in...

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Bibliographic Details
Main Authors: Shuxian Ma, Linyan Sun, Wenhao Wu, Jiangli Wu, Zhangnan Sun, Jianjun Ren
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Physiology
Subjects:
ubiquitin specific peptidase 22
myocardial ischemia–reperfusion injury
sirtuin-1
p53
solute carrier family 7 member 11
ferroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.551318/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.551318/full

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