The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis

Hitz et al. describe the role of the protein kinase PfCK2α in the development of the human malaria parasite Plasmodium falciparum. Using mutant parasites, they show that PfCK2α is not only essential for asexual but also sexual development of P. falciparum blood stage parasites, and hence it may hold...

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Main Authors:	Eva Hitz, Olivia Grüninger, Armin Passecker, Matthias Wyss, Christian Scheurer, Sergio Wittlin, Hans-Peter Beck, Nicolas M. B. Brancucci, Till S. Voss
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-03-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-01873-0

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spelling	doaj-a968a781e2a9433ca72783a35e1bac0a2021-03-14T12:14:14ZengNature Publishing GroupCommunications Biology2399-36422021-03-014111510.1038/s42003-021-01873-0The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesisEva Hitz0Olivia Grüninger1Armin Passecker2Matthias Wyss3Christian Scheurer4Sergio Wittlin5Hans-Peter Beck6Nicolas M. B. Brancucci7Till S. Voss8Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health InstituteDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health InstituteDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health InstituteDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health InstituteDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health InstituteDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health InstituteDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health InstituteDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health InstituteDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health InstituteHitz et al. describe the role of the protein kinase PfCK2α in the development of the human malaria parasite Plasmodium falciparum. Using mutant parasites, they show that PfCK2α is not only essential for asexual but also sexual development of P. falciparum blood stage parasites, and hence it may hold promise as a potential target for antimalarial drugs.https://doi.org/10.1038/s42003-021-01873-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Eva Hitz Olivia Grüninger Armin Passecker Matthias Wyss Christian Scheurer Sergio Wittlin Hans-Peter Beck Nicolas M. B. Brancucci Till S. Voss
spellingShingle	Eva Hitz Olivia Grüninger Armin Passecker Matthias Wyss Christian Scheurer Sergio Wittlin Hans-Peter Beck Nicolas M. B. Brancucci Till S. Voss The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis Communications Biology
author_facet	Eva Hitz Olivia Grüninger Armin Passecker Matthias Wyss Christian Scheurer Sergio Wittlin Hans-Peter Beck Nicolas M. B. Brancucci Till S. Voss
author_sort	Eva Hitz
title	The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis
title_short	The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis
title_full	The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis
title_fullStr	The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis
title_full_unstemmed	The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis
title_sort	catalytic subunit of plasmodium falciparum casein kinase 2 is essential for gametocytogenesis
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-03-01
description	Hitz et al. describe the role of the protein kinase PfCK2α in the development of the human malaria parasite Plasmodium falciparum. Using mutant parasites, they show that PfCK2α is not only essential for asexual but also sexual development of P. falciparum blood stage parasites, and hence it may hold promise as a potential target for antimalarial drugs.
url	https://doi.org/10.1038/s42003-021-01873-0
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The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis

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