Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence
Abstract Background Spindle assembly checkpoint components BubR1 and Sgo1 play a key role in the maintenance of chromosomal instability during cell division. These proteins function to block the anaphase entry until all condensed chromosomes have been attached by the microtubules emanating from both...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2016-02-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13045-016-0238-5 |