Salmonella effector SpvB aggravates dysregulation of systemic iron metabolism via modulating the hepcidin−ferroportin axis

Salmonella effector SpvB aggravates dysregulation of systemic iron metabolism via modulating the hepcidin−ferroportin axis

Iron withholding, an essential component of nutritional immunity, plays a fundamental role in host resistance to Salmonella infection. Our previous study showed that SpvB, an important pSLT-encoded cytotoxic effector, facilitated Salmonella pathogenesis within macrophages via perturbing cellular iro...

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Bibliographic Details
Main Authors: Qifeng Deng, Sidi Yang, Lanqing Sun, Kedi Dong, Yuanyuan Li, Shuyan Wu, Rui Huang
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Gut Microbes
Subjects:
salmonella
spvb; systemic iron metabolism
hepcidin–ferroportin axis
trem-1
Online Access:http://dx.doi.org/10.1080/19490976.2020.1849996

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