The C-terminus of Toxoplasma RON2 provides the crucial link between AMA1 and the host-associated invasion complex.
Host cell invasion by apicomplexan parasites requires formation of the moving junction (MJ), a ring-like apposition between the parasite and host plasma membranes that the parasite migrates through during entry. The Toxoplasma MJ is a secreted complex including TgAMA1, a transmembrane protein on the...
Main Authors: | Jessica S Tyler, John C Boothroyd |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-02-01
|
Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC3037364?pdf=render |
Similar Items
-
Toxoplasma gondii sporozoites invade host cells using two novel paralogues of RON2 and AMA1.
by: Anna Poukchanski, et al.
Published: (2013-01-01) -
FUNCTIONAL CONSEQUENCES OF AMA1-RON2 INTERACTION DURING HOST CELL INVASION BY <i>TOXOPLASMA</i>.
by: Krishnamurthy, Shruthi
Published: (2016) -
Not a Simple Tether: Binding of Toxoplasma gondii AMA1 to RON2 during Invasion Protects AMA1 from Rhomboid-Mediated Cleavage and Leads to Dephosphorylation of Its Cytosolic Tail
by: Shruthi Krishnamurthy, et al.
Published: (2016-09-01) -
The moving junction protein RON8 facilitates firm attachment and host cell invasion in Toxoplasma gondii.
by: Kurtis W Straub, et al.
Published: (2011-03-01) -
Significance of the entire C-terminus in biological activities mediated by the RON receptor tyrosine kinase and its oncogenic variant RON160
by: Yao Hang-Ping, et al.
Published: (2008-10-01)