Hydroxyapatite supported caesium carbonate as a new recyclable solid base catalyst for the Knoevenagel condensation in water

• Main Authors: Monika Gupta, Rajive Gupta, Medha Anand
• Format: Article
• Language: English
• Published: Beilstein-Institut 2009-11-01
• Series: Beilstein Journal of Organic Chemistry
• Subjects: ethyl cyanoacetate; hydroxyapatite supported caesium carbonate; Knoevenagel condensation; malonic acid; malononitrile
• Online Access: https://doi.org/10.3762/bjoc.5.68
• ISSN: 1860-5397

The Knoevenagel condensation between aromatic aldehydes and malononitrile, ethyl cyanoacetate or malonic acid with hydroxyapatite supported caesium carbonate in water is described. HAP–Cs2CO3 was found to be a highly active, stable and recyclable catalyst under the reaction conditions.