Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels

Ceramides are a type of sphingolipid (SL) that have been shown to play a role in several metabolic disorders. Here, the authors investigate the effect of SL-production by gut Bacteroides on host SL homeostasis and show that microbiome-derived SLs enter host circulation and alter ceramide production.

Bibliographic Details
Main Authors:	Elizabeth L. Johnson, Stacey L. Heaver, Jillian L. Waters, Benjamin I. Kim, Alexis Bretin, Andrew L. Goodman, Andrew T. Gewirtz, Tilla S. Worgall, Ruth E. Ley
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16274-w

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spelling	doaj-a946ac4716d946b782e0ae26fb93f95f2021-05-23T11:14:18ZengNature Publishing GroupNature Communications2041-17232020-05-0111111110.1038/s41467-020-16274-wSphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levelsElizabeth L. Johnson0Stacey L. Heaver1Jillian L. Waters2Benjamin I. Kim3Alexis Bretin4Andrew L. Goodman5Andrew T. Gewirtz6Tilla S. Worgall7Ruth E. Ley8Department of Microbiome Science, Max Planck Institute for Developmental BiologyDepartment of Microbiome Science, Max Planck Institute for Developmental BiologyDepartment of Microbiome Science, Max Planck Institute for Developmental BiologyDepartment of Pathology and Cell Biology, Columbia UniversityCenter for Inflammation, Immunity, and Infection, Institute for Biomedical Sciences, Georgia State UniversityDepartment of Microbial Pathogenesis, Yale University School of MedicineCenter for Inflammation, Immunity, and Infection, Institute for Biomedical Sciences, Georgia State UniversityDepartment of Pathology and Cell Biology, Columbia UniversityDepartment of Microbiome Science, Max Planck Institute for Developmental BiologyCeramides are a type of sphingolipid (SL) that have been shown to play a role in several metabolic disorders. Here, the authors investigate the effect of SL-production by gut Bacteroides on host SL homeostasis and show that microbiome-derived SLs enter host circulation and alter ceramide production.https://doi.org/10.1038/s41467-020-16274-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Elizabeth L. Johnson Stacey L. Heaver Jillian L. Waters Benjamin I. Kim Alexis Bretin Andrew L. Goodman Andrew T. Gewirtz Tilla S. Worgall Ruth E. Ley
spellingShingle	Elizabeth L. Johnson Stacey L. Heaver Jillian L. Waters Benjamin I. Kim Alexis Bretin Andrew L. Goodman Andrew T. Gewirtz Tilla S. Worgall Ruth E. Ley Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels Nature Communications
author_facet	Elizabeth L. Johnson Stacey L. Heaver Jillian L. Waters Benjamin I. Kim Alexis Bretin Andrew L. Goodman Andrew T. Gewirtz Tilla S. Worgall Ruth E. Ley
author_sort	Elizabeth L. Johnson
title	Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
title_short	Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
title_full	Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
title_fullStr	Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
title_full_unstemmed	Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
title_sort	sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-05-01
description	Ceramides are a type of sphingolipid (SL) that have been shown to play a role in several metabolic disorders. Here, the authors investigate the effect of SL-production by gut Bacteroides on host SL homeostasis and show that microbiome-derived SLs enter host circulation and alter ceramide production.
url	https://doi.org/10.1038/s41467-020-16274-w
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Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels

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