The Quest for the Best: How TCR Affinity, Avidity, and Functional Avidity Affect TCR-Engineered T-Cell Antitumor Responses

The Quest for the Best: How TCR Affinity, Avidity, and Functional Avidity Affect TCR-Engineered T-Cell Antitumor Responses

Over the past decades, adoptive transfer of T cells has revolutionized cancer immunotherapy. In particular, T-cell receptor (TCR) engineering of T cells has marked important milestones in developing more precise and personalized cancer immunotherapies. However, to get the most benefit out of this ap...

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Bibliographic Details
Main Authors: Diana Campillo-Davo, Donovan Flumens, Eva Lion
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
T-cell receptor
TCR affinity
TCR avidity
TCR engineering
T-cell fitness
affinity-enhanced
Online Access:https://www.mdpi.com/2073-4409/9/7/1720

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