Leptin and cancer: Pathogenesis and modulation

Leptin and cancer: Pathogenesis and modulation

Leptin, a product of Ob gene from adipocytes regulates appetite, energy expenditure and body mass composition by decreasing orexigenic and increasing anorexigenic neuropeptide release from hypothalamus. Research over the past few years have suggested leptin/leptin receptor dysregulation to have a ro...

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Bibliographic Details
Main Authors: Deep Dutta, Sujoy Ghosh, Kaushik Pandit, Pradip Mukhopadhyay, Subhankar Chowdhury
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2012-01-01
Series:Indian Journal of Endocrinology and Metabolism
Subjects:
Breast cancer
colorectal cancer
hepatocellular cancer
leptin
thyroid cancer
Online Access:http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=9;spage=596;epage=600;aulast=Dutta
Description
Summary:Leptin, a product of Ob gene from adipocytes regulates appetite, energy expenditure and body mass composition by decreasing orexigenic and increasing anorexigenic neuropeptide release from hypothalamus. Research over the past few years have suggested leptin/leptin receptor dysregulation to have a role in the development of a large variety of malignancies like breast ca, thyroid ca, endometrial ca and gastrointestinal malignancies, predominantly through JAK/STAT pathway which modulates PI3K/AKT3 signaling, ERK1/2 signaling, expression of antiapoptotic proteins (like XIAP), systemic inflammation (TNF-α, IL6), angiogenic factors (VEGF) and hypoxia inducible factor-1a (HIF-1a) expression. In this review, the current understanding of leptin′s role in carcinogenesis has been elaborated. Also a few agents modulating leptin signaling to inhibit cancer cell growth has been described.
ISSN:2230-8210
2230-9500

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