A Comprehensive Review of Pegvaliase, an Enzyme Substitution Therapy for the Treatment of Phenylketonuria

Objective: To review the pharmacology, pharmacokinetics, efficacy, safety, and place in therapy of a phenylalanine-metabolizing enzyme indicated to reduce blood phenylalanine concentrations, pegvaliase injection. Data Sources: Searches of MEDLINE (1946-September 1, 2018) were conducted using the ter...

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Bibliographic Details
Main Authors: Tasmina Hydery, Valerie Azzopardi Coppenrath
Format: Article
Language:English
Published: AboutScience Srl 2019-06-01
Series:Drug Target Insights
Online Access:https://doi.org/10.1177/1177392819857089