α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism

α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism

Coordinated gastrointestinal smooth muscle contraction is critical for proper nutrient absorption and is altered in a number of medical disorders. In this work, we demonstrate a critical role for the RGD-binding integrin α8β1 in promoting nutrient absorption through regulation of gastrointestinal mo...

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Bibliographic Details
Main Authors: Amin Khalifeh-Soltani, Arnold Ha, Michael J Podolsky, Donald A McCarthy, William McKleroy, Saeedeh Azary, Stephen Sakuma, Kevin M Tharp, Nanyan Wu, Yasuyuki Yokosaki, Daniel Hart, Andreas Stahl, Kamran Atabai
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-04-01
Series:eLife
Subjects:
integrin
Mfge8
PTEN
nutrient absorption
gastrointestinal motility
smooth muscle
Online Access:https://elifesciences.org/articles/13063

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