Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity

Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity

A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M pha...

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Bibliographic Details
Main Authors: Shogo Mori, Howard Williams, Davey Cagle, Kristopher Karanovich, F. David Horgen, Roger Smith III, Coran M. H. Watanabe
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Marine Drugs
Subjects:
macrolactone
polyketide
cyanobacteria
chemotaxis
cell cycle
Online Access:http://www.mdpi.com/1660-3397/13/10/6274

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