Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity

A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M pha...

Full description

Bibliographic Details
Main Authors:	Shogo Mori, Howard Williams, Davey Cagle, Kristopher Karanovich, F. David Horgen, Roger Smith III, Coran M. H. Watanabe
Format:	Article
Language:	English
Published:	MDPI AG 2015-10-01
Series:	Marine Drugs
Subjects:	macrolactone polyketide cyanobacteria chemotaxis cell cycle
Online Access:	http://www.mdpi.com/1660-3397/13/10/6274

id	doaj-a932d94d0e484730a580e970d4d6e771
record_format	Article
spelling	doaj-a932d94d0e484730a580e970d4d6e7712020-11-24T22:29:55ZengMDPI AGMarine Drugs1660-33972015-10-0113106274629010.3390/md13106274md13106274Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic ActivityShogo Mori0Howard Williams1Davey Cagle2Kristopher Karanovich3F. David Horgen4Roger Smith III5Coran M. H. Watanabe6Department of Chemistry, Texas A&M University, College Station, TX 77843, USADepartment of Chemistry, Texas A&M University, College Station, TX 77843, USADepartment of Natural Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USADepartment of Natural Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USADepartment of Natural Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USADepartment of Veterinary Pathology, Texas A&M University, College Station, TX 77843, USADepartment of Chemistry, Texas A&M University, College Station, TX 77843, USAA new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.http://www.mdpi.com/1660-3397/13/10/6274macrolactonepolyketidecyanobacteriachemotaxiscell cycle
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shogo Mori Howard Williams Davey Cagle Kristopher Karanovich F. David Horgen Roger Smith III Coran M. H. Watanabe
spellingShingle	Shogo Mori Howard Williams Davey Cagle Kristopher Karanovich F. David Horgen Roger Smith III Coran M. H. Watanabe Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity Marine Drugs macrolactone polyketide cyanobacteria chemotaxis cell cycle
author_facet	Shogo Mori Howard Williams Davey Cagle Kristopher Karanovich F. David Horgen Roger Smith III Coran M. H. Watanabe
author_sort	Shogo Mori
title	Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity
title_short	Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity
title_full	Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity
title_fullStr	Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity
title_full_unstemmed	Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity
title_sort	macrolactone nuiapolide, isolated from a hawaiian marine cyanobacterium, exhibits anti-chemotactic activity
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2015-10-01
description	A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.
topic	macrolactone polyketide cyanobacteria chemotaxis cell cycle
url	http://www.mdpi.com/1660-3397/13/10/6274
work_keys_str_mv	AT shogomori macrolactonenuiapolideisolatedfromahawaiianmarinecyanobacteriumexhibitsantichemotacticactivity AT howardwilliams macrolactonenuiapolideisolatedfromahawaiianmarinecyanobacteriumexhibitsantichemotacticactivity AT daveycagle macrolactonenuiapolideisolatedfromahawaiianmarinecyanobacteriumexhibitsantichemotacticactivity AT kristopherkaranovich macrolactonenuiapolideisolatedfromahawaiianmarinecyanobacteriumexhibitsantichemotacticactivity AT fdavidhorgen macrolactonenuiapolideisolatedfromahawaiianmarinecyanobacteriumexhibitsantichemotacticactivity AT rogersmithiii macrolactonenuiapolideisolatedfromahawaiianmarinecyanobacteriumexhibitsantichemotacticactivity AT coranmhwatanabe macrolactonenuiapolideisolatedfromahawaiianmarinecyanobacteriumexhibitsantichemotacticactivity
_version_	1725742769851334656

Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity

Similar Items