Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus.

Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus.

Vaccinia viruses have been used as a model for viral disease and as a protective live vaccine.We investigated the immunogenicity of an attenuated strain of vaccinia virus engineered to inactivate the N1L gene (vGK5). Using the intranasal route, this recombinant virus was 2 logs less virulent compare...

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Bibliographic Details
Main Authors: Anuja Mathew, Joel O'Bryan, William Marshall, Girish J Kotwal, Masanori Terajima, Sharone Green, Alan L Rothman, Francis A Ennis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2553181?pdf=render

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