Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus.
Vaccinia viruses have been used as a model for viral disease and as a protective live vaccine.We investigated the immunogenicity of an attenuated strain of vaccinia virus engineered to inactivate the N1L gene (vGK5). Using the intranasal route, this recombinant virus was 2 logs less virulent compare...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-10-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2553181?pdf=render |