Severe isoniazid related sideroblastic anemia

Severe isoniazid related sideroblastic anemia

Isoniazid induced sideroblastic anemia is a rare event. We report case of a 45 year old Caucasian women with development of severe anaemia 4 month after introduction of Isoniazid as part of Tuberculosis treatment. While haemoglobin fell to 47 g/L and erythrocyte count to 1.5 G/L, reticulocytes were...

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Main Authors: Rein Jan Piso, Kveti Kriz, Marie-Claire Desax
Format: Article
Language:English
Published: PAGEPress Publications 2011-01-01
Series:Hematology Reports
Subjects:
sideroblastic anemia
Isoniazid, Tuberculosis
Online Access:http://www.pagepress.org/journals/index.php/hr/article/view/2072
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spelling doaj-a9191ed4e1b04bfdb44443b5843702bf2020-11-25T03:44:41ZengPAGEPress PublicationsHematology Reports2038-83222038-83302011-01-0131e2e210.4081/hr.2011.e21359Severe isoniazid related sideroblastic anemiaRein Jan Piso0Kveti KrizMarie-Claire DesaxMedizinsche Klinik Kantonsspital OltenIsoniazid induced sideroblastic anemia is a rare event. We report case of a 45 year old Caucasian women with development of severe anaemia 4 month after introduction of Isoniazid as part of Tuberculosis treatment. While haemoglobin fell to 47 g/L and erythrocyte count to 1.5 G/L, reticulocytes were very low (reticulocyte production index of 0.48), but bone marrow aspirate showed an accelerated erythropoiesis with ringsideroblasts. Anaemia rapidly resolved after cessation of Isoniazid. We postulate an Isoniazid induced inhibition of the δ-Amino-levulinat-synthase resulting in marked depletion of heam synthesis.http://www.pagepress.org/journals/index.php/hr/article/view/2072sideroblastic anemiaIsoniazid, Tuberculosis
collection DOAJ
language English
format Article
sources DOAJ
author Rein Jan Piso
Kveti Kriz
Marie-Claire Desax
spellingShingle Rein Jan Piso
Kveti Kriz
Marie-Claire Desax
Severe isoniazid related sideroblastic anemia
Hematology Reports
sideroblastic anemia
Isoniazid, Tuberculosis
author_facet Rein Jan Piso
Kveti Kriz
Marie-Claire Desax
author_sort Rein Jan Piso
title Severe isoniazid related sideroblastic anemia
title_short Severe isoniazid related sideroblastic anemia
title_full Severe isoniazid related sideroblastic anemia
title_fullStr Severe isoniazid related sideroblastic anemia
title_full_unstemmed Severe isoniazid related sideroblastic anemia
title_sort severe isoniazid related sideroblastic anemia
publisher PAGEPress Publications
series Hematology Reports
issn 2038-8322
2038-8330
publishDate 2011-01-01
description Isoniazid induced sideroblastic anemia is a rare event. We report case of a 45 year old Caucasian women with development of severe anaemia 4 month after introduction of Isoniazid as part of Tuberculosis treatment. While haemoglobin fell to 47 g/L and erythrocyte count to 1.5 G/L, reticulocytes were very low (reticulocyte production index of 0.48), but bone marrow aspirate showed an accelerated erythropoiesis with ringsideroblasts. Anaemia rapidly resolved after cessation of Isoniazid. We postulate an Isoniazid induced inhibition of the δ-Amino-levulinat-synthase resulting in marked depletion of heam synthesis.
topic sideroblastic anemia
Isoniazid, Tuberculosis
url http://www.pagepress.org/journals/index.php/hr/article/view/2072
work_keys_str_mv AT reinjanpiso severeisoniazidrelatedsideroblasticanemia
AT kvetikriz severeisoniazidrelatedsideroblasticanemia
AT marieclairedesax severeisoniazidrelatedsideroblasticanemia
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