Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation
Abstract Background Secoisolariciresinol diglucoside (SDG), the main lignan in flaxseed, is known for its beneficial effects in inflammation, oxidative stress, heart disease, tumor progression, atherosclerosis, and diabetes. SDG might be an attractive natural compound that protects against neuroinfl...
Main Authors: | Slava Rom, Viviana Zuluaga-Ramirez, Nancy L. Reichenbach, Michelle A. Erickson, Malika Winfield, Sachin Gajghate, Melpo Christofidou-Solomidou, Kelly L. Jordan-Sciutto, Yuri Persidsky |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2018-01-01
|
Series: | Journal of Neuroinflammation |
Online Access: | http://link.springer.com/article/10.1186/s12974-018-1065-0 |
Similar Items
-
Synthetic Secoisolariciresinol DiglucosideAttenuates Established Pain, Oxidative Stressand Neuroinflammation in a Rodent Modelof Painful Radiculopathy
by: Sonia Kartha, et al.
Published: (2020-11-01) -
The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage
by: Anastasia Velalopoulou, et al.
Published: (2015-12-01) -
Asbestos Induces Oxidative Stress and Activation of Nrf2 Signaling in Murine Macrophages: Chemopreventive Role of the Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605)
by: Ralph A. Pietrofesa, et al.
Published: (2016-03-01) -
Combination of HIV-1 and Diabetes Enhances Blood Brain Barrier Injury via Effects on Brain Endothelium and Pericytes
by: Slava Rom, et al.
Published: (2020-06-01) -
The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages
by: Ralph A. Pietrofesa, et al.
Published: (2017-01-01)