Mesenchymal Transition of High-Grade Breast Carcinomas Depends on Extracellular Matrix Control of Myeloid Suppressor Cell Activity

Mesenchymal Transition of High-Grade Breast Carcinomas Depends on Extracellular Matrix Control of Myeloid Suppressor Cell Activity

The extracellular matrix (ECM) contributes to the biological and clinical heterogeneity of breast cancer, and different prognostic groups can be identified according to specific ECM signatures. In high-grade, but not low-grade, tumors, an ECM signature characterized by high SPARC expression (ECM3) i...

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Bibliographic Details
Main Authors: Sabina Sangaletti, Claudio Tripodo, Alessandra Santangelo, Nadia Castioni, Paola Portararo, Alessandro Gulino, Laura Botti, Mariella Parenza, Barbara Cappetti, Rosaria Orlandi, Elda Tagliabue, Claudia Chiodoni, Mario P. Colombo
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
Breast cancer
epithelial to mesenchymal transition
EMT
extracellular matrix
ECM
myeloid-derived suppressor cells
MDSC
SPARC
aminobisphosphonates
cyclooxygenase-2
COX-2
granulocyte-macrophage colony-stimulating factor
GM-CSF
granulocyte colony-stimulating factor
G-CSF
CXCL12
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716311718

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