Liposomes as non-viral carriers for genetic drugs

• Main Authors: Justyna M. Meissner, Monika Toporkiewicz, Lucyna Matusewicz, Beata Machnicka
• Format: Article
• Language: English
• Published: Index Copernicus International S.A. 2016-03-01
• Series: Postępy Higieny i Medycyny Doświadczalnej
• Subjects: terapia genowa; niewirusowe nośniki leków; liposomy; immunoliposomy; Gene Therapy; non-viral drug carriers
• Online Access: http://phmd.pl/gicid/01.3001.0009.6800

Methods in cancer therapy particularly in recent years, are rapidly changing, due to the need of design of new, more effective therapeutic strategies. Very promising approach to treatment of the neoplastic diseases is antisense gene therapy. Due to the low toxicity of treatment and eliminating not only the symptoms but also the molecular causes of the disease it may represent a breakthrough in cancer therapies. Delivery of a therapeutic DNA or RNA oligonucleotides to the target cells in vivo requires suitable carrier system. Non-viral drug carriers are increasingly used in new systems of targeted gene therapy. This review presents new generation of non-viral carriers, and is focused on immunoliposomes finding potential application in targeted gene therapy.