Refractory Toxic Shock-Like Syndrome from Streptococcus dysgalactiae ssp. equisimilis and Intravenous Immunoglobulin as Salvage Therapy: A Case Series

Refractory Toxic Shock-Like Syndrome from Streptococcus dysgalactiae ssp. equisimilis and Intravenous Immunoglobulin as Salvage Therapy: A Case Series

Infections from Streptococcus dysgalactiae ssp. equisimilis (SDSE) can cause a wide variety of infections, ranging from mild cellulitis to invasive disease, such as endocarditis and streptococcal toxic shock-like syndrome (TSLS). Despite prompt and appropriate antibiotics, mortality rates associated...

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Main Authors: Marjan Islam, Dennis Karter, Jerry Altshuler, Diana Altshuler, David Schwartz, Gianluca Torregrossa
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Case Reports in Infectious Diseases
Online Access:http://dx.doi.org/10.1155/2016/2547645
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spelling doaj-a908863491b349c5bd41455b0bd8ca7b2020-11-24T22:23:13ZengHindawi LimitedCase Reports in Infectious Diseases2090-66252090-66332016-01-01201610.1155/2016/25476452547645Refractory Toxic Shock-Like Syndrome from Streptococcus dysgalactiae ssp. equisimilis and Intravenous Immunoglobulin as Salvage Therapy: A Case SeriesMarjan Islam0Dennis Karter1Jerry Altshuler2Diana Altshuler3David Schwartz4Gianluca Torregrossa5Department of Medicine, Mount Sinai Beth Israel, New York, NY 10003, USADepartment of Medicine, Mount Sinai Beth Israel, New York, NY 10003, USADepartment of Pharmacy, Mount Sinai Beth Israel, New York, NY 10003, USADepartment of Pharmacy, NYU Langone Medical Center, New York, NY 10016, USADepartment of Medicine, NYU Langone Medical Center, New York, NY 10016, USADepartment of Cardiac Surgery, Mount Sinai Beth Israel, New York, NY 10003, USAInfections from Streptococcus dysgalactiae ssp. equisimilis (SDSE) can cause a wide variety of infections, ranging from mild cellulitis to invasive disease, such as endocarditis and streptococcal toxic shock-like syndrome (TSLS). Despite prompt and appropriate antibiotics, mortality rates associated with shock have remained exceedingly high, prompting the need for adjunctive therapy. IVIG has been proposed as a possible adjunct, given its ability to neutralize a wide variety of superantigens and modulate a dysregulated inflammatory response. We present the first reported cases of successful IVIG therapy for reversing shock in the treatment of SDSE TSLS.http://dx.doi.org/10.1155/2016/2547645
collection DOAJ
language English
format Article
sources DOAJ
author Marjan Islam
Dennis Karter
Jerry Altshuler
Diana Altshuler
David Schwartz
Gianluca Torregrossa
spellingShingle Marjan Islam
Dennis Karter
Jerry Altshuler
Diana Altshuler
David Schwartz
Gianluca Torregrossa
Refractory Toxic Shock-Like Syndrome from Streptococcus dysgalactiae ssp. equisimilis and Intravenous Immunoglobulin as Salvage Therapy: A Case Series
Case Reports in Infectious Diseases
author_facet Marjan Islam
Dennis Karter
Jerry Altshuler
Diana Altshuler
David Schwartz
Gianluca Torregrossa
author_sort Marjan Islam
title Refractory Toxic Shock-Like Syndrome from Streptococcus dysgalactiae ssp. equisimilis and Intravenous Immunoglobulin as Salvage Therapy: A Case Series
title_short Refractory Toxic Shock-Like Syndrome from Streptococcus dysgalactiae ssp. equisimilis and Intravenous Immunoglobulin as Salvage Therapy: A Case Series
title_full Refractory Toxic Shock-Like Syndrome from Streptococcus dysgalactiae ssp. equisimilis and Intravenous Immunoglobulin as Salvage Therapy: A Case Series
title_fullStr Refractory Toxic Shock-Like Syndrome from Streptococcus dysgalactiae ssp. equisimilis and Intravenous Immunoglobulin as Salvage Therapy: A Case Series
title_full_unstemmed Refractory Toxic Shock-Like Syndrome from Streptococcus dysgalactiae ssp. equisimilis and Intravenous Immunoglobulin as Salvage Therapy: A Case Series
title_sort refractory toxic shock-like syndrome from streptococcus dysgalactiae ssp. equisimilis and intravenous immunoglobulin as salvage therapy: a case series
publisher Hindawi Limited
series Case Reports in Infectious Diseases
issn 2090-6625
2090-6633
publishDate 2016-01-01
description Infections from Streptococcus dysgalactiae ssp. equisimilis (SDSE) can cause a wide variety of infections, ranging from mild cellulitis to invasive disease, such as endocarditis and streptococcal toxic shock-like syndrome (TSLS). Despite prompt and appropriate antibiotics, mortality rates associated with shock have remained exceedingly high, prompting the need for adjunctive therapy. IVIG has been proposed as a possible adjunct, given its ability to neutralize a wide variety of superantigens and modulate a dysregulated inflammatory response. We present the first reported cases of successful IVIG therapy for reversing shock in the treatment of SDSE TSLS.
url http://dx.doi.org/10.1155/2016/2547645
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