Kallikrein/K1, Kinins, and ACE/Kininase II in Homeostasis and in Disease Insight From Human and Experimental Genetic Studies, Therapeutic Implication

Kallikrein/K1, Kinins, and ACE/Kininase II in Homeostasis and in Disease Insight From Human and Experimental Genetic Studies, Therapeutic Implication

Kallikrein-K1 is the main kinin-forming enzyme in organs in resting condition and in several pathological situations whereas angiotensin I-converting enzyme/kininase II (ACE) is the main kinin-inactivating enzyme in the circulation. Both ACE and K1 activity levels are genetic traits in man. Recent r...

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Bibliographic Details
Main Authors: Francois Alhenc-Gelas, Nadine Bouby, Jean-Pierre Girolami
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Medicine
Subjects:
angiotensin-converting enzyme
kallikrein (tissue)
kinins
vasodilation
genetic human
genetic mouse models
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2019.00136/full

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