Preparation and Characterization of Vancomycin-Loaded Electrospun Rana chensinensis Skin Collagen/Poly(L-lactide) Nanofibers for Drug Delivery
Collagen was extracted from abandoned Rana chensinensis skin in northeastern China via an acid enzymatic extraction method for the use of drug carriers. In this paper we demonstrated two different nanofiber-vancomycin (VCM) systems, that is, VCM blended nanofibers and core-shell nanofibers with VCM...
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doaj-a900e83c3f2a41fc8ec0b766447debf62020-11-25T00:10:17ZengHindawi LimitedJournal of Nanomaterials1687-41101687-41292016-01-01201610.1155/2016/91593649159364Preparation and Characterization of Vancomycin-Loaded Electrospun Rana chensinensis Skin Collagen/Poly(L-lactide) Nanofibers for Drug DeliveryMei Zhang0Ziqi Li1Lihua Liu2Zhouyang Sun3Wendi Ma4Zhichao Zhang5Rui Zhang6Dahui Sun7Alan G. MacDiarmid Laboratory, College of Chemistry, Jilin University, Changchun 130012, ChinaAlan G. MacDiarmid Laboratory, College of Chemistry, Jilin University, Changchun 130012, ChinaCollege of Quartermaster Technology, Jilin University, Changchun 130062, ChinaCollege of Quartermaster Technology, Jilin University, Changchun 130062, ChinaCollege of Quartermaster Technology, Jilin University, Changchun 130062, ChinaCollege of Quartermaster Technology, Jilin University, Changchun 130062, ChinaCollege of Quartermaster Technology, Jilin University, Changchun 130062, ChinaNorman Bethune First Hospital, Jilin University, Changchun 130021, ChinaCollagen was extracted from abandoned Rana chensinensis skin in northeastern China via an acid enzymatic extraction method for the use of drug carriers. In this paper we demonstrated two different nanofiber-vancomycin (VCM) systems, that is, VCM blended nanofibers and core-shell nanofibers with VCM in the core. Rana chensinensis skin collagen (RCSC) and poly(L-lactide) (PLLA) (3 : 7) were blended in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) at a concentration of 10% (g/mL) to fabricate coaxial and blend nanofibers, respectively. Coaxial and blend electrospun RCSC/PLLA nanofibers containing VCM (5 wt%) were evaluated for the local and temporal delivery of VCM. The nanofiber scaffolds were characterized by environmental scanning electron microscope (ESEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FTIR), differential scanning calorimeter (DSC), water contact angle (WCA), and mechanical tests. The drug release of VCM in these two systems was compared by using UV spectrophotometer. The empirical result indicated that both the blend and coaxial RCSC/PLLA scaffolds followed sustained control release for a period of 80 hours, but the coaxial nanofiber might be a potential drug delivery material for its better mechanical properties and sustained release effect.http://dx.doi.org/10.1155/2016/9159364 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mei Zhang Ziqi Li Lihua Liu Zhouyang Sun Wendi Ma Zhichao Zhang Rui Zhang Dahui Sun |
spellingShingle |
Mei Zhang Ziqi Li Lihua Liu Zhouyang Sun Wendi Ma Zhichao Zhang Rui Zhang Dahui Sun Preparation and Characterization of Vancomycin-Loaded Electrospun Rana chensinensis Skin Collagen/Poly(L-lactide) Nanofibers for Drug Delivery Journal of Nanomaterials |
author_facet |
Mei Zhang Ziqi Li Lihua Liu Zhouyang Sun Wendi Ma Zhichao Zhang Rui Zhang Dahui Sun |
author_sort |
Mei Zhang |
title |
Preparation and Characterization of Vancomycin-Loaded Electrospun Rana chensinensis Skin Collagen/Poly(L-lactide) Nanofibers for Drug Delivery |
title_short |
Preparation and Characterization of Vancomycin-Loaded Electrospun Rana chensinensis Skin Collagen/Poly(L-lactide) Nanofibers for Drug Delivery |
title_full |
Preparation and Characterization of Vancomycin-Loaded Electrospun Rana chensinensis Skin Collagen/Poly(L-lactide) Nanofibers for Drug Delivery |
title_fullStr |
Preparation and Characterization of Vancomycin-Loaded Electrospun Rana chensinensis Skin Collagen/Poly(L-lactide) Nanofibers for Drug Delivery |
title_full_unstemmed |
Preparation and Characterization of Vancomycin-Loaded Electrospun Rana chensinensis Skin Collagen/Poly(L-lactide) Nanofibers for Drug Delivery |
title_sort |
preparation and characterization of vancomycin-loaded electrospun rana chensinensis skin collagen/poly(l-lactide) nanofibers for drug delivery |
publisher |
Hindawi Limited |
series |
Journal of Nanomaterials |
issn |
1687-4110 1687-4129 |
publishDate |
2016-01-01 |
description |
Collagen was extracted from abandoned Rana chensinensis skin in northeastern China via an acid enzymatic extraction method for the use of drug carriers. In this paper we demonstrated two different nanofiber-vancomycin (VCM) systems, that is, VCM blended nanofibers and core-shell nanofibers with VCM in the core. Rana chensinensis skin collagen (RCSC) and poly(L-lactide) (PLLA) (3 : 7) were blended in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) at a concentration of 10% (g/mL) to fabricate coaxial and blend nanofibers, respectively. Coaxial and blend electrospun RCSC/PLLA nanofibers containing VCM (5 wt%) were evaluated for the local and temporal delivery of VCM. The nanofiber scaffolds were characterized by environmental scanning electron microscope (ESEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FTIR), differential scanning calorimeter (DSC), water contact angle (WCA), and mechanical tests. The drug release of VCM in these two systems was compared by using UV spectrophotometer. The empirical result indicated that both the blend and coaxial RCSC/PLLA scaffolds followed sustained control release for a period of 80 hours, but the coaxial nanofiber might be a potential drug delivery material for its better mechanical properties and sustained release effect. |
url |
http://dx.doi.org/10.1155/2016/9159364 |
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