Nitric oxide alters hyaluronan deposition by airway smooth muscle cells.

Asthma is a chronic inflammatory disease that is known to cause changes in the extracellular matrix, including changes in hyaluronan (HA) deposition. However, little is known about the factors that modulate its deposition or the potential consequences. Asthmatics with high levels of exhaled nitric o...

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Bibliographic Details
Main Authors: Alana K Majors, Ritu Chakravarti, Lisa M Ruple, Rachel Leahy, Dennis J Stuehr, Mark Lauer, Serpil C Erzurum, Allison Janocha, Mark A Aronica
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0200074