Antifungal activity of some toothpastes and antiseptic solutions against yeasts isolated from the oral cavity of cancer radiated patients

• Main Author: Attia EA
• Format: Article
• Language: English
• Published: Arab Society for Fungal Conservation 2018-06-01
• Series: Microbial Biosystems Journal
• Subjects: candida; efficacy; dipodascus geotrichum; geotrichum beigelii; suez canal; university
• Online Access: https://mb.journals.ekb.eg/article_12357_7c144f8bb3afc62d05e0a0368a8c4781.pdf

This study aimed to investigate the antifungal efficacy of different types of toothpaste and<br />some antiseptic solutions with varying concentrations against yeast isolated from the oral cavity<br />of radiated patients suffering from head and neck cancer in radiotherapy unit in Suez Canal<br />University teaching’s hospital, Egypt. Eight different species of yeast were isolated<br />taxonomically, assigned to 1 phylum, two classes, one order, and three families and identified<br />phenotypically. The antifungal activity of five kinds of toothpaste and three antiseptic solutions<br />were investigated by agar well diffusion method against the eight isolated yeasts namely:<br />Candida glabrata, C. albicans, C. tropicalis, C. kefyr, C. guilliermondii, C. parapsilosis,<br />Dipodascus geotrichum and Geotrichum beigelii and expressed as the value of the clear zone<br />diameter, however, Their activity was expressed by minimum inhibitory concentration (MIC).<br />Results showed that toothpaste no 1, 3, 4 and 5 were effective against all tested taxa by variable<br />inhibitory degrees. However, no. 2 showed efficacy only against C. glabrata, C. guilliermondii,<br />and C. parapsilosis, Antiseptic solution no 1 showed the highest efficacy against all tested<br />species except C. kefyr while no. 2 was effective against all the tested species except two taxa<br />and finally no. 3 exhibited good antifungal activity against all the tested taxa. In conclusion, we<br />recommended the use of toothpaste contained sodium monofluorophosphate, or sodium fluoride,<br />as an active component followed by a mouthwash which contained Chlorohexidine or<br />Cetylpridinium or miswak as active components to prevent colonization and development of oral<br />candidiasis, especially in cancer patients.