Impaired Inactivation of L-Type Ca2+ Current as a Potential Mechanism for Variable Arrhythmogenic Liability of HERG K+ Channel Blocking Drugs.

Impaired Inactivation of L-Type Ca2+ Current as a Potential Mechanism for Variable Arrhythmogenic Liability of HERG K+ Channel Blocking Drugs.

The proarrhythmic effects of new drugs have been assessed by measuring rapidly activating delayed-rectifier K+ current (IKr) antagonist potency. However, recent data suggest that even drugs thought to be highly specific IKr blockers can be arrhythmogenic via a separate, time-dependent pathway such a...

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Bibliographic Details
Main Authors: Jae Gon Kim, Dong Jun Sung, Hyun-ji Kim, Sang Woong Park, Kyung Jong Won, Bokyung Kim, Ho Chul Shin, Ki-Suk Kim, Chae Hun Leem, Yin Hua Zhang, Hana Cho, Young Min Bae
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4772914?pdf=render

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