Hepatitis C virus NS4B targets lipid droplets through hydrophobic residues in the amphipathic helices[S]

Hepatitis C virus NS4B targets lipid droplets through hydrophobic residues in the amphipathic helices[S]

Lipid droplets (LD) are dynamic storage organelles that are involved in lipid homeostasis. Hepatitis C virus (HCV) is closely associated with LDs. HCV Core and nonstructural (NS) proteins colocalize with LDs and presumably are involved in virion formation at that site. We demonstrated that HCV NS4B,...

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Bibliographic Details
Main Authors: Torahiko Tanaka, Kazumichi Kuroda, Masanori Ikeda, Takaji Wakita, Nobuyuki Kato, Makoto Makishima
Format: Article
Language:English
Published: Elsevier 2013-04-01
Series:Journal of Lipid Research
Subjects:
alanine substitution
confocal imaging
JFH1
RNA transfection
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520421960

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