DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy

DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy

Abstract Background Sex is an important covariate of epigenome-wide association studies due to its strong influence on DNA methylation patterns across numerous genomic positions. Nevertheless, many samples on the Gene Expression Omnibus (GEO) frequently lack a sex annotation or are incorrectly label...

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Bibliographic Details
Main Authors: Yucheng Wang, Eilis Hannon, Olivia A. Grant, Tyler J. Gorrie-Stone, Meena Kumari, Jonathan Mill, Xiaojun Zhai, Klaus D. McDonald-Maier, Leonard C. Schalkwyk
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Genomics
Subjects:
DNA methylation
Sex prediction
Aneuploidy
Online Access:https://doi.org/10.1186/s12864-021-07675-2

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