Transient Secondary Structures as General Target-Binding Motifs in Intrinsically Disordered Proteins

Transient Secondary Structures as General Target-Binding Motifs in Intrinsically Disordered Proteins

Intrinsically disordered proteins (IDPs) are unorthodox proteins that do not form three-dimensional structures under non-denaturing conditions, but perform important biological functions. In addition, IDPs are associated with many critical diseases including cancers, neurodegenerative diseases, and...

Full description

Bibliographic Details
Main Authors:	Do-Hyoung Kim, Kyou-Hoon Han
Format:	Article
Language:	English
Published:	MDPI AG 2018-11-01
Series:	International Journal of Molecular Sciences
Subjects:	intrinsically disordered protein (IDP) pre-populated transient secondary structure pre-structured
Online Access:	https://www.mdpi.com/1422-0067/19/11/3614

Similar Items

Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins
by: Estella A. Newcombe, et al.
Published: (2021-08-01)

Salient Features of Monomeric Alpha-Synuclein Revealed by NMR Spectroscopy
by: Do-Hyoung Kim, et al.
Published: (2020-03-01)

Interplay of Structural Disorder and Short Binding Elements in the Cellular Chaperone Function of Plant Dehydrin ERD14
by: Nikoletta Murvai, et al.
Published: (2020-08-01)

Intrinsically Disordered Proteins and Their “Mysterious” (Meta)Physics
by: Vladimir N. Uversky, et al.
Published: (2019-02-01)

Computational Approaches for Inferring the Functions of Intrinsically Disordered Proteins
by: Mihaly eVaradi, et al.
Published: (2015-08-01)

Single Molecule FRET: A Powerful Tool to Study Intrinsically Disordered Proteins
by: Sharonda J. LeBlanc, et al.
Published: (2018-11-01)

Spontaneous Switching among Conformational Ensembles in Intrinsically Disordered Proteins
by: Ucheor B. Choi, et al.
Published: (2019-03-01)

Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function
by: Benjamin Bourgeois, et al.
Published: (2021-07-01)

Troubleshooting Guide to Expressing Intrinsically Disordered Proteins for Use in NMR Experiments
by: Steffen P. Graether
Published: (2019-01-01)

Intrinsically Disordered Side of the Zika Virus Proteome
by: Rajanish Giri, et al.
Published: (2016-11-01)

Sequence and Structure Properties Uncover the Natural Classification of Protein Complexes Formed by Intrinsically Disordered Proteins via Mutual Synergistic Folding
by: Bálint Mészáros, et al.
Published: (2019-11-01)

Cellular Chaperone Function of Intrinsically Disordered Dehydrin ERD14
by: Nikoletta Murvai, et al.
Published: (2021-06-01)

p53 Phosphomimetics Preserve Transient Secondary Structure but Reduce Binding to Mdm2 and MdmX
by: Robin Levy, et al.
Published: (2019-03-01)

NeProc predicts binding segments in intrinsically disordered regions without learning binding region sequences
by: Hiroto Anbo, et al.
Published: (2020-11-01)

The Paralogue of the Intrinsically Disordered Nuclear Protein 1 Has a Nuclear Localization Sequence that Binds to Human Importin α3
by: José L. Neira, et al.
Published: (2020-10-01)

Development of Charge-Augmented Three-Point Water Model (CAIPi3P) for Accurate Simulations of Intrinsically Disordered Proteins
by: Joao V. de Souza, et al.
Published: (2020-08-01)

The Brain's Intrinsic Spatiotemporal Structure and Its Potential Application in Artificial Intelligence
by: Golesorkhi, Mehrshad
Published: (2021)

Globular and disordered – the non-identical twins in protein-protein interactions
by: Kaare eTeilum, et al.
Published: (2015-07-01)

COMPUTER METHODS FOR PRE-MICRORNA SECONDARY STRUCTURE PREDICTION
by: Han, Dianwei
Published: (2012)

Characterization of AMBN I and II Isoforms and Study of Their Ca<sup>2+</sup>-Binding Properties
by: Veronika Vetyskova, et al.
Published: (2020-12-01)

Effect of Post-Translational Amidation on Islet Amyloid Polypeptide Conformational Ensemble: Implications for Its Aggregation Early Steps
by: Linh Tran, et al.
Published: (2016-11-01)

The Poly-E motif in Titin's PEVK region undergoes pH dependent conformational changes
by: Dassanayake Mudiyanselage Sudarshi Premawardhana, et al.
Published: (2020-12-01)

Sequence Versus Composition: What Prescribes IDP Biophysical Properties?
by: Jiří Vymětal, et al.
Published: (2019-07-01)

Hormonal modulation of breast cancer gene expression: implications for intrinsic subtyping in pre-menopausal women
by: Sarah M Bernhardt, et al.
Published: (2016-11-01)

Seeing Keratinocyte Proteins through the Looking Glass of Intrinsic Disorder
by: Rambon Shamilov, et al.
Published: (2021-07-01)

Physicochemical studies on interaction between intrinsically disordered regions in transcription factors Sp1 and TAF4
by: Hibino, Emi
Published: (2017)

Evolution of A bHLH Interaction Motif
by: Peter S. Millard, et al.
Published: (2021-01-01)

Connecting the αα-hubs: same fold, disordered ligands, new functions
by: Lasse Staby, et al.
Published: (2021-01-01)

Structure, Dynamics, and Evolution of the Intrinsically Disordered p53 Transactivation Domain
by: Borcherds, Wade Michael
Published: (2013)

IDP–CRF: Intrinsically Disordered Protein/Region Identification Based on Conditional Random Fields
by: Yumeng Liu, et al.
Published: (2018-08-01)

Roles, Characteristics, and Analysis of Intrinsically Disordered Proteins: A Minireview
by: Frederik Lermyte
Published: (2020-11-01)

Conserved glycine residues control transient helicity and disorder in the cold regulated protein, Cor15a
by: Sowemimo, Oluwakemi
Published: (2019)

Stabilization of Intrinsically Disordered DKK2 Protein by Fusion to RNA-Binding Domain
by: Hye Min Lee, et al.
Published: (2019-06-01)

Conserved Outer Tegument Component UL11 from Herpes Simplex Virus 1 Is an Intrinsically Disordered, RNA-Binding Protein
by: Claire M. Metrick, et al.
Published: (2020-05-01)

Malleable ribonucleoprotein machine: protein intrinsic disorder in the Saccharomyces cerevisiae spliceosome
by: Maria de Lourdes Coelho Ribeiro, et al.
Published: (2013-02-01)

Large-Scale Analyses of Site-Specific Evolutionary Rates across Eukaryote Proteomes Reveal Confounding Interactions between Intrinsic Disorder, Secondary Structure, and Functional Domains
by: Joseph B. Ahrens, et al.
Published: (2018-11-01)

Transient Unfolding and Long-Range Interactions in Viral BCL2 M11 Enable Binding to the BECN1 BH3 Domain
by: Arvind Ramanathan, et al.
Published: (2020-09-01)

Structure Determination by Single-Particle Cryo-Electron Microscopy: Only the Sky (and Intrinsic Disorder) is the Limit
by: Emeka Nwanochie, et al.
Published: (2019-08-01)

Investigating the Contribution of Disordered Domains to the Biological Activity of RNA-binding Proteins
by: Tavella, Davide
Published: (2018)

On the roles of intrinsically disordered proteins and regions in cell communication and signaling
by: Sarah E. Bondos, et al.
Published: (2021-08-01)

Cannot write session to /tmp/vufind_sessions/sess_8jrtaeh841c08fls7fhno7k98d