Novel Segmented Concentration Addition Method to Predict Mixture Hormesis of Chlortetracycline Hydrochloride and Oxytetracycline Hydrochloride to <i>Aliivibrio fischeri</i>

Novel Segmented Concentration Addition Method to Predict Mixture Hormesis of Chlortetracycline Hydrochloride and Oxytetracycline Hydrochloride to <i>Aliivibrio fischeri</i>

Hormesis is a concentration-response phenomenon characterized by low-concentration stimulation and high-concentration inhibition, which typically has a nonmonotonic J-shaped concentration-response curve (J-CRC). The concentration addition (CA) model is the gold standard for studying mixture toxicity...

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Bibliographic Details
Main Authors: Huilin Ge, Min Zhou, Daizhu Lv, Mingyue Wang, Defang Xie, Xinfeng Yang, Cunzhu Dong, Shuhuai Li, Peng Lin
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
antibiotics
<i>aliivibrio fischeri</i>
mixture hormesis
cross point hypothesis
concentration addition
isobole
co-toxicity coefficient
antagonism
Online Access:https://www.mdpi.com/1422-0067/21/2/481

Internet

https://www.mdpi.com/1422-0067/21/2/481

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