Age-Based Dynamics of a Stable Circulating Cd8 T Cell Repertoire Component

Age-Based Dynamics of a Stable Circulating Cd8 T Cell Repertoire Component

T-cell memory to pathogens can be envisioned as a receptor-based imprint of the pathogenic environment on the naïve repertoire of clonotypes. Recurrent exposures to a pathogen inform and reinforce memory, leading to a mature state. The complexity and temporal stability of this system in man is only...

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Bibliographic Details
Main Authors: Elena N. Naumova, Maryam B. Yassai, Wendy Demos, Erica Reed, Melissa Unruh, Dipica Haribhai, Calvin B. Williams, Yuri N. Naumov, Jack Gorski
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
human CD8 T cells
computational immunology
repertoire maturation
circulation as depot
senescence
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01717/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01717/full

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