Prioritized High-Confidence Risk Genes for Intellectual Disability Reveal Molecular Convergence During Brain Development

Prioritized High-Confidence Risk Genes for Intellectual Disability Reveal Molecular Convergence During Brain Development

Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DNMs) will aid our understanding of the neurobiological and genetic basis of ID. In this study, we identify 63 high-confidence ID genes with q-values < 0.1 based on four background DNM rates and...

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Bibliographic Details
Main Authors: Zhenwei Liu, Na Zhang, Yu Zhang, Yaoqiang Du, Tao Zhang, Zhongshan Li, Jinyu Wu, Xiaobing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Genetics
Subjects:
intellectual disability
de novo mutations
brain development
gene prioritization
molecular convergence
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00349/full

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