Formulating a Stable Mannitol Infusion while Maintaining Hyperosmolarity

Formulating a Stable Mannitol Infusion while Maintaining Hyperosmolarity

Mannitol infusion is commonly used in the treatment of intracranial hypertension following traumatic brain injury. It has long been known to have stability issues, specifically, mannitol recrystallises from solutions greater than 10% <i>w</i>/<i>v</i> in ambient conditions. T...

Full description

Bibliographic Details
Main Authors: Oisín Kavanagh, Fiona Hogan, Caoimhe Murphy, Denise Croker, Gavin Walker
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Pharmaceutics
Subjects:
mannitol instability
raised intracranial pressure
intracranial hypertension
traumatic brain injury
reformulation
mannitol
recrystallisation
Online Access:https://www.mdpi.com/1999-4923/12/2/187

Internet

https://www.mdpi.com/1999-4923/12/2/187

Similar Items