A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells

A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells

Margaret O’Connor et al. report a new Innate Lymphoid Cell population in human tonsils and lymph nodes that inhibit the functional interaction of follicular helper T cells and germinal center B cells. They show that this cell population is expanded under chronic HIV infection and results in decrease...

Full description

Bibliographic Details
Main Authors: Margaret H. O’Connor, Roshell Muir, Marita Chakhtoura, Michael Fang, Eirini Moysi, Susan Moir, Alison J. Carey, Alyssa Terk, Carmen N. Nichols, Talibah Metcalf, Constantinos Petrovas, Mark J. Cameron, Virginie Tardif, Elias K. Haddad
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02079-0
id doaj-a866230b1fdc4b2fb508ecc62a24397c
record_format Article
spelling doaj-a866230b1fdc4b2fb508ecc62a24397c2021-05-16T11:21:11ZengNature Publishing GroupCommunications Biology2399-36422021-05-014111310.1038/s42003-021-02079-0A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cellsMargaret H. O’Connor0Roshell Muir1Marita Chakhtoura2Michael Fang3Eirini Moysi4Susan Moir5Alison J. Carey6Alyssa Terk7Carmen N. Nichols8Talibah Metcalf9Constantinos Petrovas10Mark J. Cameron11Virginie Tardif12Elias K. Haddad13The Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of MedicineThe Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of MedicineThe Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of MedicineThe Department of Population and Quantitative Health Services, Case Western Reserve UniversityTissue Analysis Core, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of HealthThe Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of HealthThe Department of Microbiology and Immunology, Drexel University College of MedicineDepartment of Pediatrics, St. Christopher’s Hospital for Children, Drexel University College of MedicineThe Department of Population and Quantitative Health Services, Case Western Reserve UniversityThe Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of MedicineTissue Analysis Core, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of HealthThe Department of Population and Quantitative Health Services, Case Western Reserve UniversityThe Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of MedicineThe Department of Medicine, Division of Infectious Diseases & HIV Medicine, Drexel University College of MedicineMargaret O’Connor et al. report a new Innate Lymphoid Cell population in human tonsils and lymph nodes that inhibit the functional interaction of follicular helper T cells and germinal center B cells. They show that this cell population is expanded under chronic HIV infection and results in decreased antibody production, suggesting a potential role for these cells in diseases with dysregulated immune responses.https://doi.org/10.1038/s42003-021-02079-0
collection DOAJ
language English
format Article
sources DOAJ
author Margaret H. O’Connor
Roshell Muir
Marita Chakhtoura
Michael Fang
Eirini Moysi
Susan Moir
Alison J. Carey
Alyssa Terk
Carmen N. Nichols
Talibah Metcalf
Constantinos Petrovas
Mark J. Cameron
Virginie Tardif
Elias K. Haddad
spellingShingle Margaret H. O’Connor
Roshell Muir
Marita Chakhtoura
Michael Fang
Eirini Moysi
Susan Moir
Alison J. Carey
Alyssa Terk
Carmen N. Nichols
Talibah Metcalf
Constantinos Petrovas
Mark J. Cameron
Virginie Tardif
Elias K. Haddad
A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells
Communications Biology
author_facet Margaret H. O’Connor
Roshell Muir
Marita Chakhtoura
Michael Fang
Eirini Moysi
Susan Moir
Alison J. Carey
Alyssa Terk
Carmen N. Nichols
Talibah Metcalf
Constantinos Petrovas
Mark J. Cameron
Virginie Tardif
Elias K. Haddad
author_sort Margaret H. O’Connor
title A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells
title_short A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells
title_full A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells
title_fullStr A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells
title_full_unstemmed A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells
title_sort follicular regulatory innate lymphoid cell population impairs interactions between germinal center tfh and b cells
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-05-01
description Margaret O’Connor et al. report a new Innate Lymphoid Cell population in human tonsils and lymph nodes that inhibit the functional interaction of follicular helper T cells and germinal center B cells. They show that this cell population is expanded under chronic HIV infection and results in decreased antibody production, suggesting a potential role for these cells in diseases with dysregulated immune responses.
url https://doi.org/10.1038/s42003-021-02079-0
work_keys_str_mv AT margarethoconnor afollicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT roshellmuir afollicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT maritachakhtoura afollicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT michaelfang afollicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT eirinimoysi afollicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT susanmoir afollicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT alisonjcarey afollicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT alyssaterk afollicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT carmennnichols afollicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT talibahmetcalf afollicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT constantinospetrovas afollicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT markjcameron afollicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT virginietardif afollicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT eliaskhaddad afollicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT margarethoconnor follicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT roshellmuir follicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT maritachakhtoura follicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT michaelfang follicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT eirinimoysi follicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT susanmoir follicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT alisonjcarey follicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT alyssaterk follicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT carmennnichols follicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT talibahmetcalf follicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT constantinospetrovas follicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT markjcameron follicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT virginietardif follicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
AT eliaskhaddad follicularregulatoryinnatelymphoidcellpopulationimpairsinteractionsbetweengerminalcentertfhandbcells
_version_ 1721439615060017152

Similar Items