Clinicopathological and prognostic significance and molecular mechanisms governing uveal melanoma

Clinicopathological and prognostic significance and molecular mechanisms governing uveal melanoma

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Although UM and cutaneous melanoma are derived from melanocytes, UM differs clinically and biologically from its more common skin counterparts. More than half of primary UMs metastasize. However, there is currently no e...

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Main Authors: Meng-Yu Wu, Tzu-Ting Lai, Wan-Ting Liao, Chia-Jung Li
Format: Article
Language:English
Published: SAGE Publishing 2020-06-01
Series:Therapeutic Advances in Medical Oncology
Online Access:https://doi.org/10.1177/1758835920917566
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spelling doaj-a862cae56cd04b0fb6d3cc163f69c4652020-11-25T03:34:52ZengSAGE PublishingTherapeutic Advances in Medical Oncology1758-83592020-06-011210.1177/1758835920917566Clinicopathological and prognostic significance and molecular mechanisms governing uveal melanomaMeng-Yu WuTzu-Ting LaiWan-Ting LiaoChia-Jung LiUveal melanoma (UM) is the most common primary intraocular malignancy in adults. Although UM and cutaneous melanoma are derived from melanocytes, UM differs clinically and biologically from its more common skin counterparts. More than half of primary UMs metastasize. However, there is currently no effective treatment for metastatic UM. Therefore, studying mutations related to the metastasis, growth, proliferation, and survival of UM can help researchers understand its pathogenesis and metastatic mechanism, thereby leading to a more effective treatment. In addition, we provide an overview of the recent basic and clinical studies to provide a strong foundation for developing novel anti-carcinogenesis targets for future interventions.https://doi.org/10.1177/1758835920917566
collection DOAJ
language English
format Article
sources DOAJ
author Meng-Yu Wu
Tzu-Ting Lai
Wan-Ting Liao
Chia-Jung Li
spellingShingle Meng-Yu Wu
Tzu-Ting Lai
Wan-Ting Liao
Chia-Jung Li
Clinicopathological and prognostic significance and molecular mechanisms governing uveal melanoma
Therapeutic Advances in Medical Oncology
author_facet Meng-Yu Wu
Tzu-Ting Lai
Wan-Ting Liao
Chia-Jung Li
author_sort Meng-Yu Wu
title Clinicopathological and prognostic significance and molecular mechanisms governing uveal melanoma
title_short Clinicopathological and prognostic significance and molecular mechanisms governing uveal melanoma
title_full Clinicopathological and prognostic significance and molecular mechanisms governing uveal melanoma
title_fullStr Clinicopathological and prognostic significance and molecular mechanisms governing uveal melanoma
title_full_unstemmed Clinicopathological and prognostic significance and molecular mechanisms governing uveal melanoma
title_sort clinicopathological and prognostic significance and molecular mechanisms governing uveal melanoma
publisher SAGE Publishing
series Therapeutic Advances in Medical Oncology
issn 1758-8359
publishDate 2020-06-01
description Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Although UM and cutaneous melanoma are derived from melanocytes, UM differs clinically and biologically from its more common skin counterparts. More than half of primary UMs metastasize. However, there is currently no effective treatment for metastatic UM. Therefore, studying mutations related to the metastasis, growth, proliferation, and survival of UM can help researchers understand its pathogenesis and metastatic mechanism, thereby leading to a more effective treatment. In addition, we provide an overview of the recent basic and clinical studies to provide a strong foundation for developing novel anti-carcinogenesis targets for future interventions.
url https://doi.org/10.1177/1758835920917566
work_keys_str_mv AT mengyuwu clinicopathologicalandprognosticsignificanceandmolecularmechanismsgoverninguvealmelanoma
AT tzutinglai clinicopathologicalandprognosticsignificanceandmolecularmechanismsgoverninguvealmelanoma
AT wantingliao clinicopathologicalandprognosticsignificanceandmolecularmechanismsgoverninguvealmelanoma
AT chiajungli clinicopathologicalandprognosticsignificanceandmolecularmechanismsgoverninguvealmelanoma
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