Antioxidant properties of saffron stigma and petals: A potential therapeutic approach for insulin resistance through an insulin-sensitizing adipocytokine in high-calorie diet rats

Background: Oxidative stress and alteration of lipid profile due to obesity and overweight is a major risk factor for atherosclerotic plaque or coronary artery disease. Because of antioxidant and lipid lowering potential of saffron, this study investigated weight alteration, lipid profiles, and insu...

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Main Authors: Zabihullah Mohaqiq, Maryam Moossavi, Mina Hemmati, Tooba Kazemi, Omid Mehrpour
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:International Journal of Preventive Medicine
Subjects:
Online Access:http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2020;volume=11;issue=1;spage=184;epage=184;aulast=Mohaqiq
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spelling doaj-a85c77890774460fa8f70c85108d6aba2021-01-08T03:43:42ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132020-01-0111118418410.4103/ijpvm.IJPVM_275_19Antioxidant properties of saffron stigma and petals: A potential therapeutic approach for insulin resistance through an insulin-sensitizing adipocytokine in high-calorie diet ratsZabihullah MohaqiqMaryam MoossaviMina HemmatiTooba KazemiOmid MehrpourBackground: Oxidative stress and alteration of lipid profile due to obesity and overweight is a major risk factor for atherosclerotic plaque or coronary artery disease. Because of antioxidant and lipid lowering potential of saffron, this study investigated weight alteration, lipid profiles, and insulin resistance index in high-calorie diet rats treated with aqueous extract of saffron stigma and petal. Methods: Forty Sprague-Dawley male rats were randomly divided into 8 groups including healthy control, high-fat diet control, nicotinic acid treated, Anethum graveolens treated, and saffron stigma and petal treated groups. Rats received a high-calorie diet for 16 weeks. For treatment, aqueous extract of saffron stigma (40 and 80 mg/kg) and petal (50 and 100 mg/kg) was used once daily for 4 weeks. Afterward, lipid profile, oxidative stress status, and insulin and adiponectin levels were measured using desired kits. Results: There was a significant decrease in the mean weight of the groups receiving saffron stigma and petal compared to control group (P < 0.05). The increased level of insulin hormone in obese group was improved in treated groups especially in the case of saffron stigma. Also, the decreased level of adiponectin was recovered in treated groups. An improvement was seen in oxidative stress markers and lipid profiles in treated groups compared to obesity pair. Conclusions: In this study, a remarkable antioxidant and lipid lowering potential was detected for saffron stigma, which could improve insulin resistance in obese rats. Therapeutic and protective effect of saffron is mainly related to its richness in phenolic compounds. Saffron stigma compared with petal had more notable effect, which could and should be mentioned in pharmaceutical studies.http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2020;volume=11;issue=1;spage=184;epage=184;aulast=Mohaqiqadipocytokineantioxidantscrocus sativusdiethigh fatinsulin resistance
collection DOAJ
language English
format Article
sources DOAJ
author Zabihullah Mohaqiq
Maryam Moossavi
Mina Hemmati
Tooba Kazemi
Omid Mehrpour
spellingShingle Zabihullah Mohaqiq
Maryam Moossavi
Mina Hemmati
Tooba Kazemi
Omid Mehrpour
Antioxidant properties of saffron stigma and petals: A potential therapeutic approach for insulin resistance through an insulin-sensitizing adipocytokine in high-calorie diet rats
International Journal of Preventive Medicine
adipocytokine
antioxidants
crocus sativus
diet
high fat
insulin resistance
author_facet Zabihullah Mohaqiq
Maryam Moossavi
Mina Hemmati
Tooba Kazemi
Omid Mehrpour
author_sort Zabihullah Mohaqiq
title Antioxidant properties of saffron stigma and petals: A potential therapeutic approach for insulin resistance through an insulin-sensitizing adipocytokine in high-calorie diet rats
title_short Antioxidant properties of saffron stigma and petals: A potential therapeutic approach for insulin resistance through an insulin-sensitizing adipocytokine in high-calorie diet rats
title_full Antioxidant properties of saffron stigma and petals: A potential therapeutic approach for insulin resistance through an insulin-sensitizing adipocytokine in high-calorie diet rats
title_fullStr Antioxidant properties of saffron stigma and petals: A potential therapeutic approach for insulin resistance through an insulin-sensitizing adipocytokine in high-calorie diet rats
title_full_unstemmed Antioxidant properties of saffron stigma and petals: A potential therapeutic approach for insulin resistance through an insulin-sensitizing adipocytokine in high-calorie diet rats
title_sort antioxidant properties of saffron stigma and petals: a potential therapeutic approach for insulin resistance through an insulin-sensitizing adipocytokine in high-calorie diet rats
publisher Wolters Kluwer Medknow Publications
series International Journal of Preventive Medicine
issn 2008-7802
2008-8213
publishDate 2020-01-01
description Background: Oxidative stress and alteration of lipid profile due to obesity and overweight is a major risk factor for atherosclerotic plaque or coronary artery disease. Because of antioxidant and lipid lowering potential of saffron, this study investigated weight alteration, lipid profiles, and insulin resistance index in high-calorie diet rats treated with aqueous extract of saffron stigma and petal. Methods: Forty Sprague-Dawley male rats were randomly divided into 8 groups including healthy control, high-fat diet control, nicotinic acid treated, Anethum graveolens treated, and saffron stigma and petal treated groups. Rats received a high-calorie diet for 16 weeks. For treatment, aqueous extract of saffron stigma (40 and 80 mg/kg) and petal (50 and 100 mg/kg) was used once daily for 4 weeks. Afterward, lipid profile, oxidative stress status, and insulin and adiponectin levels were measured using desired kits. Results: There was a significant decrease in the mean weight of the groups receiving saffron stigma and petal compared to control group (P < 0.05). The increased level of insulin hormone in obese group was improved in treated groups especially in the case of saffron stigma. Also, the decreased level of adiponectin was recovered in treated groups. An improvement was seen in oxidative stress markers and lipid profiles in treated groups compared to obesity pair. Conclusions: In this study, a remarkable antioxidant and lipid lowering potential was detected for saffron stigma, which could improve insulin resistance in obese rats. Therapeutic and protective effect of saffron is mainly related to its richness in phenolic compounds. Saffron stigma compared with petal had more notable effect, which could and should be mentioned in pharmaceutical studies.
topic adipocytokine
antioxidants
crocus sativus
diet
high fat
insulin resistance
url http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2020;volume=11;issue=1;spage=184;epage=184;aulast=Mohaqiq
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