Differential autophagy power in the spinal cord and muscle of transgenic ALS mice.

Differential autophagy power in the spinal cord and muscle of transgenic ALS mice.

Amyotrophic lateral sclerosis (ALS) is a motoneuron disease characterized by misfolded proteins aggregation in affected motoneurons. In mutant SOD1 (mutSOD1) ALS models, aggregation correlates to impaired functions of proteasome and/or autophagy, both essential for the intracellular chaperone-mediat...

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Main Authors: Valeria eCrippa, Alessandra eBoncoraglio, Mariarita eGalbiati, Tanya eAggarwal, Paola eRusmini, Elisa eGiorgetti, Riccardo eCristofani, Serena eCarra, Maria ePennuto, Angelo ePoletti
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Amyotrophic Lateral Sclerosis
Autophagy
motoneurons
protein quality control
HSPB8
BAG3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00234/full

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