Development of a human leukocyte antigen-based HIV vaccine [version 1; referees: 2 approved]
Human immunodeficiency virus (HIV) carries abundant human cell proteins, particularly human leukocyte antigen (HLA) molecules when the virus leaves host cells. Immunization in macaques with HLAs protects the animals from simian immunodeficiency virus infection. This finding offers an alternative app...
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F1000 Research Ltd
2018-06-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/7-874/v1 |
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doaj-a8587c2621b54166a46d8598ba72de632020-11-25T02:55:14ZengF1000 Research LtdF1000Research2046-14022018-06-01710.12688/f1000research.13759.114952Development of a human leukocyte antigen-based HIV vaccine [version 1; referees: 2 approved]Yufei Wang0Mucosal Immunology Unit, Dental Institute, Kings College London, Guy’s Campus, London Bridge, London, SE1 9RT, UKHuman immunodeficiency virus (HIV) carries abundant human cell proteins, particularly human leukocyte antigen (HLA) molecules when the virus leaves host cells. Immunization in macaques with HLAs protects the animals from simian immunodeficiency virus infection. This finding offers an alternative approach to the development of HLA molecule-based HIV vaccines. Decades of studies have enhanced a great deal of our understanding of the mechanisms of allo-immune response-mediated anti-HIV immunity. These include cell-mediated immunity, innate immunity, and antibody response. These studies provided a rationale for the future design of effective HIV vaccines.https://f1000research.com/articles/7-874/v1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yufei Wang |
| spellingShingle |
Yufei Wang Development of a human leukocyte antigen-based HIV vaccine [version 1; referees: 2 approved] F1000Research |
| author_facet |
Yufei Wang |
| author_sort |
Yufei Wang |
| title |
Development of a human leukocyte antigen-based HIV vaccine [version 1; referees: 2 approved] |
| title_short |
Development of a human leukocyte antigen-based HIV vaccine [version 1; referees: 2 approved] |
| title_full |
Development of a human leukocyte antigen-based HIV vaccine [version 1; referees: 2 approved] |
| title_fullStr |
Development of a human leukocyte antigen-based HIV vaccine [version 1; referees: 2 approved] |
| title_full_unstemmed |
Development of a human leukocyte antigen-based HIV vaccine [version 1; referees: 2 approved] |
| title_sort |
development of a human leukocyte antigen-based hiv vaccine [version 1; referees: 2 approved] |
| publisher |
F1000 Research Ltd |
| series |
F1000Research |
| issn |
2046-1402 |
| publishDate |
2018-06-01 |
| description |
Human immunodeficiency virus (HIV) carries abundant human cell proteins, particularly human leukocyte antigen (HLA) molecules when the virus leaves host cells. Immunization in macaques with HLAs protects the animals from simian immunodeficiency virus infection. This finding offers an alternative approach to the development of HLA molecule-based HIV vaccines. Decades of studies have enhanced a great deal of our understanding of the mechanisms of allo-immune response-mediated anti-HIV immunity. These include cell-mediated immunity, innate immunity, and antibody response. These studies provided a rationale for the future design of effective HIV vaccines. |
| url |
https://f1000research.com/articles/7-874/v1 |
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AT yufeiwang developmentofahumanleukocyteantigenbasedhivvaccineversion1referees2approved |
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