Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning

Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning

Abstract Background Human microbiota-associated (HMA) animal models relying on germ-free recipient mice are being used to study the relationship between intestinal microbiota and human disease. However, transfer of microbiota into germ-free animals also triggers global developmental changes in the r...

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Bibliographic Details
Main Authors: Christopher Staley, Thomas Kaiser, Lalit K. Beura, Matthew J. Hamilton, Alexa R. Weingarden, Aleh Bobr, Johnthomas Kang, David Masopust, Michael J. Sadowsky, Alexander Khoruts
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Microbiome
Subjects:
Antibiotics
Fecal microbiota transplantation
Germ-free
Humanization
Mouse model
Online Access:http://link.springer.com/article/10.1186/s40168-017-0306-2

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