Murine Double Minute 2 Gene (MDM2) rs937283A/G variant significantly increases the susceptibility to breast cancer in Saudi Women
Breast cancer is predominant causes of mortality in women worldwide. Genetic polymorphisms have a significant role in breast cancer aetiology. TP53 and its inhibitor the murine double minute 2 (MDM2) genes encode proteins that have crucial functions in the DNA damage response. The allelic variations...
Main Authors: | Weam Talal Yehya Shebli, Mohammad Kdaimes H. Alotibi, Rawya Ibrahim AL-Raddadi, Razan Jamaan Al-amri, Emad Ibrahim Yagoub Fallatah, Ahmed Safar Alhujaily, Hiba Salaheldin Mohamed |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-04-01
|
Series: | Saudi Journal of Biological Sciences |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1319562X21000231 |
Similar Items
-
Impact of the MDM2 splice-variants MDM2-A, MDM2-B and MDM2-C on cytotoxic stress response in breast cancer cells
by: Johanna Huun, et al.
Published: (2017-04-01) -
Associations of MDM2 and MDM4 Polymorphisms with Early-Stage Breast Cancer
by: Agnė Bartnykaitė, et al.
Published: (2021-02-01) -
Regulation of the tumor suppressor p53 by Mdm2 and Mdm4
by: Maetens, Marion
Published: (2007) -
Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells
by: Zuzana Mrkvová, et al.
Published: (2019-06-01) -
Targeting MDM4 Splicing in Cancers
by: Boris Bardot, et al.
Published: (2017-02-01)