Targeting Tumor Microenvironment by Small-Molecule Inhibitors

The tumor microenvironment (TME) is a hypoxic, acidic, and immune/inflammatory cell–enriched milieu that plays crucial roles in tumor development, growth, progression, and therapy resistance. Targeting TME is an attractive strategy for the treatment of solid tumors. Conventional cancer chemotherapie...

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Main Authors:	Shangwei Zhong, Ji-Hak Jeong, Zhikang Chen, Zihua Chen, Jun-Li Luo
Format:	Article
Language:	English
Published:	Elsevier 2020-01-01
Series:	Translational Oncology
Online Access:	http://www.sciencedirect.com/science/article/pii/S1936523319304966

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spelling	doaj-a84240d146b843b989b0b7a9343faba72020-11-25T01:29:33ZengElsevierTranslational Oncology1936-52332020-01-011315769Targeting Tumor Microenvironment by Small-Molecule InhibitorsShangwei Zhong0Ji-Hak Jeong1Zhikang Chen2Zihua Chen3Jun-Li Luo4The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Hunan, 410008, China; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USADepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USAThe Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Hunan, 410008, China; Zihua Chen or Zhikang Chen, The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Hunan 410008, ChinaThe Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Hunan, 410008, China; Zihua Chen or Zhikang Chen, The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Hunan 410008, ChinaDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA; Address all correspondence to: Jun-Li Luo, Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA.The tumor microenvironment (TME) is a hypoxic, acidic, and immune/inflammatory cell–enriched milieu that plays crucial roles in tumor development, growth, progression, and therapy resistance. Targeting TME is an attractive strategy for the treatment of solid tumors. Conventional cancer chemotherapies are mostly designed to directly kill cancer cells, and the effectiveness is always compromised by their penetration and accessibility to cancer cells. Small-molecule inhibitors, which exhibit good penetration and accessibility, are widely studied, and many of them have been successfully applied in clinics for cancer treatment. As TME is more penetrable and accessible than tumor cells, a lot of efforts have recently been made to generate small-molecule inhibitors that specifically target TME or the components of TME or develop special drug-delivery systems that release the cytotoxic drugs specifically in TME. In this review, we briefly summarize the recent advances of small-molecule inhibitors that target TME for the tumor treatment.http://www.sciencedirect.com/science/article/pii/S1936523319304966
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shangwei Zhong Ji-Hak Jeong Zhikang Chen Zihua Chen Jun-Li Luo
spellingShingle	Shangwei Zhong Ji-Hak Jeong Zhikang Chen Zihua Chen Jun-Li Luo Targeting Tumor Microenvironment by Small-Molecule Inhibitors Translational Oncology
author_facet	Shangwei Zhong Ji-Hak Jeong Zhikang Chen Zihua Chen Jun-Li Luo
author_sort	Shangwei Zhong
title	Targeting Tumor Microenvironment by Small-Molecule Inhibitors
title_short	Targeting Tumor Microenvironment by Small-Molecule Inhibitors
title_full	Targeting Tumor Microenvironment by Small-Molecule Inhibitors
title_fullStr	Targeting Tumor Microenvironment by Small-Molecule Inhibitors
title_full_unstemmed	Targeting Tumor Microenvironment by Small-Molecule Inhibitors
title_sort	targeting tumor microenvironment by small-molecule inhibitors
publisher	Elsevier
series	Translational Oncology
issn	1936-5233
publishDate	2020-01-01
description	The tumor microenvironment (TME) is a hypoxic, acidic, and immune/inflammatory cell–enriched milieu that plays crucial roles in tumor development, growth, progression, and therapy resistance. Targeting TME is an attractive strategy for the treatment of solid tumors. Conventional cancer chemotherapies are mostly designed to directly kill cancer cells, and the effectiveness is always compromised by their penetration and accessibility to cancer cells. Small-molecule inhibitors, which exhibit good penetration and accessibility, are widely studied, and many of them have been successfully applied in clinics for cancer treatment. As TME is more penetrable and accessible than tumor cells, a lot of efforts have recently been made to generate small-molecule inhibitors that specifically target TME or the components of TME or develop special drug-delivery systems that release the cytotoxic drugs specifically in TME. In this review, we briefly summarize the recent advances of small-molecule inhibitors that target TME for the tumor treatment.
url	http://www.sciencedirect.com/science/article/pii/S1936523319304966
work_keys_str_mv	AT shangweizhong targetingtumormicroenvironmentbysmallmoleculeinhibitors AT jihakjeong targetingtumormicroenvironmentbysmallmoleculeinhibitors AT zhikangchen targetingtumormicroenvironmentbysmallmoleculeinhibitors AT zihuachen targetingtumormicroenvironmentbysmallmoleculeinhibitors AT junliluo targetingtumormicroenvironmentbysmallmoleculeinhibitors
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Targeting Tumor Microenvironment by Small-Molecule Inhibitors

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