Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles
An effective approach for amino protection and construction of a seven-membered ring has been developed. The method uses imidazolium chloride to carry out the Michael addition reaction at low temperatures and perform amino deprotection or construction of a seven-membered ring at high temperatures.
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| Language: | English |
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MDPI AG
2019-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/23/4224 |
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doaj-a83d9d5eb025475183658017c05877262020-11-25T01:58:53ZengMDPI AGMolecules1420-30492019-11-012423422410.3390/molecules24234224molecules24234224Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring HeterocyclesZeshu Dai0Qingqiang Tian1Yanwu Li2Suqin Shang3Wen Luo4Xuetong Wang5Dan Li6Ying Zhang7Zhiyao Li8Jianyong Yuan9Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, ChinaAn effective approach for amino protection and construction of a seven-membered ring has been developed. The method uses imidazolium chloride to carry out the Michael addition reaction at low temperatures and perform amino deprotection or construction of a seven-membered ring at high temperatures.https://www.mdpi.com/1420-3049/24/23/4224imidazolium chlorideamino protectionmichael addition reactionamino deprotectionsolvent-freeseven-membered ring |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Zeshu Dai Qingqiang Tian Yanwu Li Suqin Shang Wen Luo Xuetong Wang Dan Li Ying Zhang Zhiyao Li Jianyong Yuan |
| spellingShingle |
Zeshu Dai Qingqiang Tian Yanwu Li Suqin Shang Wen Luo Xuetong Wang Dan Li Ying Zhang Zhiyao Li Jianyong Yuan Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles Molecules imidazolium chloride amino protection michael addition reaction amino deprotection solvent-free seven-membered ring |
| author_facet |
Zeshu Dai Qingqiang Tian Yanwu Li Suqin Shang Wen Luo Xuetong Wang Dan Li Ying Zhang Zhiyao Li Jianyong Yuan |
| author_sort |
Zeshu Dai |
| title |
Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles |
| title_short |
Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles |
| title_full |
Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles |
| title_fullStr |
Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles |
| title_full_unstemmed |
Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles |
| title_sort |
michael addition reaction catalyzed by imidazolium chloride to protect amino groups and construct medium ring heterocycles |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2019-11-01 |
| description |
An effective approach for amino protection and construction of a seven-membered ring has been developed. The method uses imidazolium chloride to carry out the Michael addition reaction at low temperatures and perform amino deprotection or construction of a seven-membered ring at high temperatures. |
| topic |
imidazolium chloride amino protection michael addition reaction amino deprotection solvent-free seven-membered ring |
| url |
https://www.mdpi.com/1420-3049/24/23/4224 |
| work_keys_str_mv |
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