E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation

E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation

<p>Abstract</p> <p>Background</p> <p>PUMA is a pro-apoptotic Bcl-2 family member that has been shown to be involved in apoptosis in many cell types. We sought to ascertain whether induction of PUMA plays a crucial role in E2F-1-induced apoptosis in melanoma cells.</p...

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Bibliographic Details
Main Authors: Zhou H Sam, Gomez-Gutierrez Jorge G, Bowling Maria T, Dong Yanbin, Hao Hongying, McMasters Kelly M
Format: Article
Language:English
Published: BMC 2007-01-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/7/24

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