Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Objective. To systematically evaluate the diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. Methods. We searched EMBASE (OvidSP), MEDLINE (OvidSP), the Cochrane Library, and Web of Science to identify diagnostic accuracy trials of monofilament tests for detectin...

Full description

Bibliographic Details
Main Authors: Fengyi Wang, Jiaqi Zhang, Jiadan Yu, Shaxin Liu, Rengang Zhang, Xichao Ma, Yonghong Yang, Pu Wang
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2017/8787261
id doaj-a83284006c4741469b89f550cf592759
record_format Article
spelling doaj-a83284006c4741469b89f550cf5927592020-11-24T22:20:48ZengHindawi LimitedJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/87872618787261Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-AnalysisFengyi Wang0Jiaqi Zhang1Jiadan Yu2Shaxin Liu3Rengang Zhang4Xichao Ma5Yonghong Yang6Pu Wang7Rehabilitation Medicine Center, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong KongWest China School of Medicine, Sichuan University, Chengdu, ChinaRehabilitation Medicine Center, West China Hospital of Sichuan University, Chengdu, ChinaRehabilitation Medicine Center, West China Hospital of Sichuan University, Chengdu, ChinaRehabilitation Medicine Center, West China Hospital of Sichuan University, Chengdu, ChinaRehabilitation Medicine Center, West China Hospital of Sichuan University, Chengdu, ChinaRui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaObjective. To systematically evaluate the diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. Methods. We searched EMBASE (OvidSP), MEDLINE (OvidSP), the Cochrane Library, and Web of Science to identify diagnostic accuracy trials of monofilament tests for detecting diabetic peripheral neuropathy. We used a hierarchical summary receiver operating characteristics (HSROC) model to conduct the meta-analysis of diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. Results. A total of 19 comparative trials met the inclusion criteria and were part of the qualitative synthesis. Eight trials using nerve conduction studies as the reference standard were selected for the meta-analysis. The pooled sensitivity and specificity of monofilament tests for detecting diabetic peripheral neuropathy were 0.53 (95% confidence interval (CI) 0.32 to 0.74) and 0.88 (95% CI 0.78 to 0.94), respectively. The pooled positive likelihood ratio and negative likelihood ratio were 4.56 (95% CI 2.93 to 7.10) and 0.53 (95% CI 0.35 to 0.81), respectively. Conclusions. Our review indicated that monofilament tests had limited sensitivity for screening diabetic peripheral neuropathy. The clinical use of the monofilament test in the evaluation of diabetic peripheral neuropathy cannot be encouraged based on currently available evidence.http://dx.doi.org/10.1155/2017/8787261
collection DOAJ
language English
format Article
sources DOAJ
author Fengyi Wang
Jiaqi Zhang
Jiadan Yu
Shaxin Liu
Rengang Zhang
Xichao Ma
Yonghong Yang
Pu Wang
spellingShingle Fengyi Wang
Jiaqi Zhang
Jiadan Yu
Shaxin Liu
Rengang Zhang
Xichao Ma
Yonghong Yang
Pu Wang
Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis
Journal of Diabetes Research
author_facet Fengyi Wang
Jiaqi Zhang
Jiadan Yu
Shaxin Liu
Rengang Zhang
Xichao Ma
Yonghong Yang
Pu Wang
author_sort Fengyi Wang
title Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis
title_short Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis
title_full Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis
title_fullStr Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis
title_full_unstemmed Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis
title_sort diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy: a systematic review and meta-analysis
publisher Hindawi Limited
series Journal of Diabetes Research
issn 2314-6745
2314-6753
publishDate 2017-01-01
description Objective. To systematically evaluate the diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. Methods. We searched EMBASE (OvidSP), MEDLINE (OvidSP), the Cochrane Library, and Web of Science to identify diagnostic accuracy trials of monofilament tests for detecting diabetic peripheral neuropathy. We used a hierarchical summary receiver operating characteristics (HSROC) model to conduct the meta-analysis of diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. Results. A total of 19 comparative trials met the inclusion criteria and were part of the qualitative synthesis. Eight trials using nerve conduction studies as the reference standard were selected for the meta-analysis. The pooled sensitivity and specificity of monofilament tests for detecting diabetic peripheral neuropathy were 0.53 (95% confidence interval (CI) 0.32 to 0.74) and 0.88 (95% CI 0.78 to 0.94), respectively. The pooled positive likelihood ratio and negative likelihood ratio were 4.56 (95% CI 2.93 to 7.10) and 0.53 (95% CI 0.35 to 0.81), respectively. Conclusions. Our review indicated that monofilament tests had limited sensitivity for screening diabetic peripheral neuropathy. The clinical use of the monofilament test in the evaluation of diabetic peripheral neuropathy cannot be encouraged based on currently available evidence.
url http://dx.doi.org/10.1155/2017/8787261
work_keys_str_mv AT fengyiwang diagnosticaccuracyofmonofilamenttestsfordetectingdiabeticperipheralneuropathyasystematicreviewandmetaanalysis
AT jiaqizhang diagnosticaccuracyofmonofilamenttestsfordetectingdiabeticperipheralneuropathyasystematicreviewandmetaanalysis
AT jiadanyu diagnosticaccuracyofmonofilamenttestsfordetectingdiabeticperipheralneuropathyasystematicreviewandmetaanalysis
AT shaxinliu diagnosticaccuracyofmonofilamenttestsfordetectingdiabeticperipheralneuropathyasystematicreviewandmetaanalysis
AT rengangzhang diagnosticaccuracyofmonofilamenttestsfordetectingdiabeticperipheralneuropathyasystematicreviewandmetaanalysis
AT xichaoma diagnosticaccuracyofmonofilamenttestsfordetectingdiabeticperipheralneuropathyasystematicreviewandmetaanalysis
AT yonghongyang diagnosticaccuracyofmonofilamenttestsfordetectingdiabeticperipheralneuropathyasystematicreviewandmetaanalysis
AT puwang diagnosticaccuracyofmonofilamenttestsfordetectingdiabeticperipheralneuropathyasystematicreviewandmetaanalysis
_version_ 1725773933193461760