FOXN3 Regulates Hepatic Glucose Utilization
A SNP (rs8004664) in the first intron of the FOXN3 gene is associated with human fasting blood glucose. We find that carriers of the risk allele have higher hepatic expression of the transcriptional repressor FOXN3. Rat Foxn3 protein and zebrafish foxn3 transcripts are downregulated during fasting,...
Main Authors: | Santhosh Karanth, Erin K. Zinkhan, Jonathon T. Hill, H. Joseph Yost, Amnon Schlegel |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2016-06-01
|
Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124716306544 |
Similar Items
-
FOXN3 controls liver glucose metabolism by regulating gluconeogenic substrate selection
by: Santhosh Karanth, et al.
Published: (2019-09-01) -
A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose
by: Santhosh Karanth, et al.
Published: (2018-07-01) -
The Monocarboxylate Transporter SLC16A6 Regulates Adult Length in Zebrafish and Is Associated With Height in Humans
by: Santhosh Karanth, et al.
Published: (2019-01-01) -
Prenatal Exposure to a Maternal High Fat Diet Increases Hepatic Cholesterol Accumulation in Intrauterine Growth Restricted Rats in Part Through MicroRNA-122 Inhibition of Cyp7a1
by: Erin K. Zinkhan, et al.
Published: (2018-05-01) -
Conversion of the Thymus into a Bipotent Lymphoid Organ by Replacement of Foxn1 with Its Paralog, Foxn4
by: Jeremy B. Swann, et al.
Published: (2014-08-01)