Immunoproteasome Function in Normal and Malignant Hematopoiesis

Immunoproteasome Function in Normal and Malignant Hematopoiesis

The ubiquitin–proteasome system (UPS) is a central part of protein homeostasis, degrading not only misfolded or oxidized proteins but also proteins with essential functions. The fact that a healthy hematopoietic system relies on the regulation of protein homeostasis and that alterations in the UPS c...

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Bibliographic Details
Main Authors: Nuria Tubío-Santamaría, Frédéric Ebstein, Florian H. Heidel, Elke Krüger
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
ubiquitin–proteasome system (UPS)
immunoproteasome (iP)
proteasome inhibitors (PIs)
hematopoiesis
hematologic malignancies
Online Access:https://www.mdpi.com/2073-4409/10/7/1577

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