Epigenetic Input Dictates the Threshold of Targeting of the Integrin-Dependent Pathway in Non-small Cell Lung Cancer

Epigenetic Input Dictates the Threshold of Targeting of the Integrin-Dependent Pathway in Non-small Cell Lung Cancer

We investigated the therapeutic potential of targeting integrin/FAK-dependent signaling, an adhesion receptor-mediated pathway that has been increasingly linked to non-small cell lung cancer (NSCLC) malignancy. Our analysis of the TCGA cohort showed that a subset of pro-tumorigenic integrins, includ...

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Bibliographic Details
Main Authors: Yang Zhang, Kai Cheng, Bingwei Xu, Junfeng Shi, Jun Qiang, Shujin Shi, Yuanqin Yi, Hongxia Li, Tengchuan Jin, Ruihua Guo, Yadi Wu, Zeyi Liu, Xiaowei Wei, Jian-An Huang, Xiuwei H. Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
lung cancer
FAK
BRD4
integrins
KRAS targeted therapy
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00652/full

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