Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance

Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance

Antibiotics targeting cell wall synthesis display an unexplained gap between in vivo efficacy and in vitro binding affinity for their target. Here, Piepenbreier et al. develop a model for bacterial cell wall biosynthesis, show how it is affected by antibiotics, and use it to predict in vivo efficacy...

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Bibliographic Details
Main Authors: Hannah Piepenbreier, Angelika Diehl, Georg Fritz
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10673-4
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spelling doaj-a814415456d14601a61c11483ea4c6602021-05-11T12:01:21ZengNature Publishing GroupNature Communications2041-17232019-06-0110111310.1038/s41467-019-10673-4Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistanceHannah Piepenbreier0Angelika Diehl1Georg Fritz2LOEWE  Center  for Synthetic Microbiology, Philipps-Universität MarburgLOEWE  Center  for Synthetic Microbiology, Philipps-Universität MarburgLOEWE  Center  for Synthetic Microbiology, Philipps-Universität MarburgAntibiotics targeting cell wall synthesis display an unexplained gap between in vivo efficacy and in vitro binding affinity for their target. Here, Piepenbreier et al. develop a model for bacterial cell wall biosynthesis, show how it is affected by antibiotics, and use it to predict in vivo efficacy of antibiotics.https://doi.org/10.1038/s41467-019-10673-4
collection DOAJ
language English
format Article
sources DOAJ
author Hannah Piepenbreier
Angelika Diehl
Georg Fritz
spellingShingle Hannah Piepenbreier
Angelika Diehl
Georg Fritz
Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance
Nature Communications
author_facet Hannah Piepenbreier
Angelika Diehl
Georg Fritz
author_sort Hannah Piepenbreier
title Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance
title_short Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance
title_full Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance
title_fullStr Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance
title_full_unstemmed Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance
title_sort minimal exposure of lipid ii cycle intermediates triggers cell wall antibiotic resistance
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-06-01
description Antibiotics targeting cell wall synthesis display an unexplained gap between in vivo efficacy and in vitro binding affinity for their target. Here, Piepenbreier et al. develop a model for bacterial cell wall biosynthesis, show how it is affected by antibiotics, and use it to predict in vivo efficacy of antibiotics.
url https://doi.org/10.1038/s41467-019-10673-4
work_keys_str_mv AT hannahpiepenbreier minimalexposureoflipidiicycleintermediatestriggerscellwallantibioticresistance
AT angelikadiehl minimalexposureoflipidiicycleintermediatestriggerscellwallantibioticresistance
AT georgfritz minimalexposureoflipidiicycleintermediatestriggerscellwallantibioticresistance
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